CD16 (FCGR3A) Human Recombinant Protein
CAT＃: TP721248
PE Conjugated Human CD16a Protein (C-His, 176V)
View other "CD16" proteins (13)
|
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CNY 3480.00
Product images
CNY 1999.00
CNY 3600.00
Specifications
| Product Data | |
| Species | Human |
| Expression Host | HEK293 |
| Expression cDNA Clone or AA Sequence |
Gly17-Gln208
|
| Tag | C-His |
| Predicted MW | The protein has the predicted molecular weight of 24 kDa and migrates at approximately 40-50 kDa on SDS-PAGE with DTT-reduced condition before PE conjugation. |
| Concentration | 25µg size is bottled at 0.1mg/mL concentration. 100 µg size is bottled at lot specific concentration. |
| Purity | >90% |
| Conjugation | PE |
| Buffer | 1xPBS buffer, pH7.4, 0.09% NaN3 with a carrier protein |
| Preparation | Affinity Ni-NTA |
| Applications | FACS |
| Storage | An unopened vial can be stored at 4°C for 2 weeks or at -20°C and below for six months. This stock solution should be aliquoted and stored at ≤ -70°C to minimize the freeze/thaw cycles. |
| Stability | 6 Months |
| Bioactivity | PositiveThe definition of the active protein (purified and biotinylated) is defined as the protein that can bind to its biological receptor/ligand. For conjugated protein, it is defined with its function to bind to the ScFv of the active CAR-transfected cells in flow cytometry test. |
| Reference Data | |
| RefSeq | NP_001121068 |
| Locus ID | 2214 |
| UniProt ID | P08637 |
| Summary | CD16a (FCGR3A) and its homolog CD16b are receptors for the Fc portion of human IgG. In contrast to CD64, which is a high affinity Fc binding protein, both CD16a and CD16b can bind Fc portion of human IgG with relative low affinity. Human CD16a is expressed mainly on natural killer cells, macrophages, T cells, and monocytes. While human CD16b is expressed on Neutrophils and eosinophils. In human cells, a single nucleotide polymorphism (T230A) creates a high binding (176V) and a low binding (176F) variant. Clinically, mutations in CD16a have been linked to vulnerability to viral infections, alloimmune neonatal neutropenia, and systemic lupus erythematosus. |
| Protein Families | FACS |
| Protein Pathways | Fc gamma R-mediated phagocytosis, Natural killer cell mediated cytotoxicity, Systemic lupus erythematosus |
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Other Versions
| SKU | Description | Size | Price |
|---|---|---|---|
| LC400194 | FCGR3A HEK293T cell transient overexpression lysate (as WB positive control) |
CNY 900.00 |
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| LC426815 | FCGR3A HEK293T cell transient overexpression lysate (as WB positive control) |
CNY 900.00 |
|
| LC426817 | FCGR3A HEK293T cell transient overexpression lysate (as WB positive control) |
CNY 900.00 |
|
| LY400194 | Transient overexpression lysate of Fc fragment of IgG, low affinity IIIa, receptor (CD16a) (FCGR3A), transcript variant 1 |
CNY 3080.00 |
|
| LY426815 | Transient overexpression lysate of Fc fragment of IgG, low affinity IIIa, receptor (CD16a) (FCGR3A), transcript variant 3 |
CNY 3080.00 |
|
| LY426817 | Transient overexpression lysate of Fc fragment of IgG, low affinity IIIa, receptor (CD16a) (FCGR3A), transcript variant 5 |
CNY 3080.00 |
|
| PH306429 | FCGR3A MS Standard C13 and N15-labeled recombinant protein (NP_000560) |
CNY 19520.00 |
|
| TP306429 | Recombinant protein of human Fc fragment of IgG, low affinity IIIa, receptor (CD16a) (FCGR3A), transcript variant 1, 20 µg |
CNY 2900.00 |
|
| TP721246 | Human CD16a Protein (C-His-Avi, 176V) |
CNY 2450.00 |
|
| TP721247 | Biotinylated Human CD16a Protein (C-His-Avi, 176V) |
CNY 3480.00 |
|
| TP721249 | APC Conjugated Human CD16a Protein (C-His, 176V) |
CNY 3480.00 |
|
| TP723977 | Human FCGR3A Protein, His Tag |
CNY 4925.00 |
|
| TP762433 | Purified recombinant protein of Human Fc fragment of IgG, low affinity IIIa, receptor (CD16a) (FCGR3A), transcript variant 3, Leu13-Gln208, with N-terminal His tag, expressed in E.coli, 50ug |
CNY 1950.00 |
