IL1 beta (IL1B) (NM_000576) Human Recombinant Protein
CAT＃: TP721175
Purified recombinant protein of Human interleukin 1, beta (IL1B)
View other "IL1 beta" proteins (7)
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CNY 1800.00
Product images
CNY 1999.00
CNY 2700.00
Specifications
| Product Data | |
| Species | Human |
| Expression Host | E. coli |
| Expression cDNA Clone or AA Sequence |
Met1-Leu586
|
| Tag | Tag Free |
| Predicted MW | 17.4 kDa |
| Concentration | lot specific |
| Purity | >95% as determined by SDS-PAGE and Coomassie blue staining |
| Buffer | Supplied as a 0.2 um filtered solution of 10mM HEPES, pH 7.4. |
| Storage | Store at < -20°C, stable for 6 months after receipt. Please minimize freeze-thaw cycles. |
| Stability | Stable for at least 6 months from date of receipt under proper storage and handling conditions. |
| Endotoxin | Endotoxin level is < 0.1 ng/µg of protein (< 1 EU/µg) |
| Reference Data | |
| RefSeq | NP_000567 |
| Locus ID | 3553 |
| UniProt ID | P01584 |
| Refseq Size | 1498 |
| Cytogenetics | 2q14.1 |
| Refseq ORF | 807 |
| Synonyms | IL-1; IL1-BETA; IL1beta; IL1F2 |
| Summary | The protein encoded by this gene is a member of the interleukin 1 cytokine family. This cytokine is produced by activated macrophages as a proprotein, which is proteolytically processed to its active form by caspase 1 (CASP1/ICE). This cytokine is an important mediator of the inflammatory response, and is involved in a variety of cellular activities, including cell proliferation, differentiation, and apoptosis. The induction of cyclooxygenase-2 (PTGS2/COX2) by this cytokine in the central nervous system (CNS) is found to contribute to inflammatory pain hypersensitivity. Similarly, IL-1B has been implicated in human osteoarthritis pathogenesis. Patients with severe Coronavirus Disease 2019 (COVID-19) present elevated levels of pro-inflammatory cytokines such as IL-1B in bronchial alveolar lavage fluid samples. The lung damage induced by the Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is to a large extent, a result of the inflammatory response promoted by cytokines such as IL-1B. This gene and eight other interleukin 1 family genes form a cytokine gene cluster on chromosome 2. [provided by RefSeq, Jul 2020] |
| Protein Families | Druggable Genome, Secreted Protein |
| Protein Pathways | Alzheimer's disease, Apoptosis, Cytokine-cytokine receptor interaction, Cytosolic DNA-sensing pathway, Graft-versus-host disease, Hematopoietic cell lineage, MAPK signaling pathway, NOD-like receptor signaling pathway, Prion diseases, Toll-like receptor signaling pathway, Type I diabetes mellitus |
Documents
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Resources
| 蛋白相关资源 |
Other Versions
| SKU | Description | Size | Price |
|---|---|---|---|
| LC400196 | IL1B HEK293T cell transient overexpression lysate (as WB positive control) |
CNY 900.00 |
|
| LY400196 | Transient overexpression lysate of interleukin 1, beta (IL1B) |
CNY 3080.00 |
|
| PH302079 | IL1B MS Standard C13 and N15-labeled recombinant protein (NP_000567) |
CNY 19520.00 |
|
| TP302079 | Recombinant protein of human interleukin 1, beta (IL1B), 20 µg |
CNY 2900.00 |
|
| TP721027 | Purified recombinant protein of Human interleukin 1, beta (IL1B) |
CNY 1800.00 |
|
| TP723772 | Purified recombinant protein of Human interleukin 1, beta (IL1B) |
CNY 4970.00 |
|
| TP750014 | Recombinant protein of human IL 1 beta (IL1B) produced in E. coli. |
CNY 2040.00 |
其它IL1 beta产品
IL1B mouse monoclonal antibody, clone OTI3E1 (formerly 3E1)
