Ipo4 (NM_024267) Mouse Recombinant Protein

Specifications

Product Data
Species	Mouse
Expression Host	HEK293T
Expression cDNA Clone or AA Sequence	Protein Sequence (showhide) >MR220703 representing NM_024267 Red=Cloning site Green=Tags(s) MEPAGLEQILKELLLPDTERIRRATEQLQTILRDPAALPALFDLLATATDSQIRQFAAVLTRRRLNNRWR RLAPEQRESLKSLVLTALQKETVHSVSVSLAQLSATIFRKEGLQGWPQFMNLLQHSTHSSHSPEKEVGLL LLSVVVSSQPEAFHAHQHELLQLLNETLSDVSFPGVLFYSLRTLTAIARYVRPDDVSLARMLVPKVVTAL RTLIPLDEVKACEALEALDEMLETELPIINPHLSEVLTFCLEVAKNVALGEPLRVRVLCCLTFLVKVKSK ALLKNRLVPPLLHALFPLMAAEPPMGQLDPEDQDSDDDDLEIGLMGETPKHFAVQVVDMLALHLPPEKLC PHVMPMLEEALRSEDPYQRKAGFLVLAVLSDGAGDHIRQRLLYPLLQIVCKGLDDPSQIVRNAALFALGQ FSENLQPHISSYSEEVMPLLLSYLKSVPMGNTHHLAKACYALENFVENLGPKVQPYLPELMECMLQPLKN PSKARTKELAVSAIGAIATAAQDSLLPYFPTIMDLLREFLLTGHEDFHLVQIQSLETLGVLARALGESMK PLAEECCQLGLGLCIHIDDPDVRRCTYSLFAALSGLMGEGLGPYLPQITTLMLLSLRSTEGIVPQYDGIS SFLLFDDDSEAEEEEELMDEDMEEEGDDSEISGYSVENAFFDEKEDTCTALGEISMNTCVAFLPFMDATF DEVYKLLECPHMNVRKSAYEALGQFCCALHKASQRSSSDPSSSPVLQTSLARVMPAYMQAVKVERERPVV MAVLESLTGVLRTCGSLALQPPGRLSELCNVLKAVLQKKTACQDAEEDDDEDDDQAEYDAMLLEHAGEAI PVLAATAGGHAFAPFFATFLPLLLCKTKQSCTVAEKSFAVGTLAESIQGLGTASAQFVSRLFPVLLNNAR EADPEVRSNAIFGLGVLAEHGGCPAQDHFPKLLGLLLPLLARERHDRVRDNICGALARVLMASPVGKTEP QVLATLLRALPLKEDMEEWLTIGHLFSFLHQNNPEQVVDVASELLRICSLILPDNRIPPDTKAALLLLLT FLAKQHTDSFHTALGSLPNDKAQELQAMMGLT TRTRPLEQKLISEEDLAANDILDYKDDDDKV
Tag	C-MYC/DDK
Predicted MW	119.3 kDa
Concentration	>0.05 µg/µL as determined by microplate BCA method
Purity	> 80% as determined by SDS-PAGE and Coomassie blue staining
Buffer	25 mM Tris-HCl, 100 mM glycine, pH 7.3, 10% glycerol
Note	For testing in cell culture applications, please filter before use. Note that you may experience some loss of protein during the filtration process.
Storage	Store at -80°C after receiving vials.
Stability	Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
Reference Data
RefSeq	NP_077229
Locus ID	75751
UniProt ID	Q8VI75
Refseq Size	3611
Cytogenetics	14 28.19 cM
Refseq ORF	3246
Synonyms	8430408O15Rik; AA409693; Imp4a; RanBP4
Summary	Functions in nuclear protein import as nuclear transport receptor. Serves as receptor for nuclear localization signals (NLS) in cargo substrates. Is thought to mediate docking of the importin/substrate complex to the nuclear pore complex (NPC) through binding to nucleoporin and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to the importin, the importin/substrate complex dissociates and importin is re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus (By similarity). Mediates the nuclear import of RPS3A. Acts as chaperone for exposed basic domains.[UniProtKB/Swiss-Prot Function]

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