Pask (NM_080850) Mouse Recombinant Protein

Specifications

Product Data
Species	Mouse
Expression Host	HEK293T
Expression cDNA Clone or AA Sequence	Protein Sequence (showhide) >MR218778 representing NM_080850 Red=Cloning site Green=Tags(s) MEDRGPPVFAEDWKCLSESPPVQEGPAAQATFEPSKPLSIAHKHLSRKNGLSRLCQSRMALSEDRWSSYC LSSLAAQNICTSKLHCAAAPEYADPTAGPLGSTSCCSLLRGLASGCSGSLLSTPVCNPNKAVFTVDAKTT EILVANDKACSLLGYSSHDLIGQKLAQFFLKSDSEVVEALSEEHVEADGHAAVVFGTVVDIVSRIGEKIP VSVWIKRLQQDRGLCCVVVLEPVERVSAWVAFQSDGTITSCDSLFAHLHGFTSPKDVVGQCVIDLIPSMQ LPPPGQHIPKSLKIQRSVGRARDGTTFPLSLKLKSKPSGRAVADSEAASEPGYQASVWVFCTISGLITLL PDGTIYGVNHSFALMLFGYGKTELLGKNITFLIPGFYHYMDLTYDSSVQLPDLVNCLDIGRKSGPGEMNS DAQHNWELASGAQGPRIDVVLARDHMPSQDETLKLVGGQVSSRTQTRLETGYKILPSSACQPSLGVDSNP EDGEQSLLTDQQSIPKRNLPAHGGQNQLDTSEISLPVLKEHLLSEIQKNISEESPLTHRKWLSKVQQNPT KGSLPIHEEQLLFAGQHIHVLGKEDPSAAESYRESLLEESKSKPVDAKLFASCEDSEPLVSVKDRGSSVD TCNLHQEAQLELMGVSSPNPWADATMPEPHTTGQIAGGSLTYCPQYRSEWASQQRGQDSAPSPSGMACVL LGTPTLDEPWPGVRNDREELQTCLIKEQLSKSSCEGNLGISRVELVPEEHPPFTAPVSFCDLGGRDLHAS RSGSSSACYALATDLPGVLEAVEAQEADVNSYSWNLKELFLKDQTDRTPSHCSCTTSELSEAPSLSVVGS DLDVGILHRQTSDILVDREMLLLTGTYFDLSEGQRFQEMGAGHDRAELSNISLVSSEHYETSDIESPGCD PPLPDPGPNDMCLSAEKPRPSAQITSTPVARGATSLQQEIQEGIYSGSCYHRDGLQLSIQFEVKRVELQG SATLFCCWLVKDLFHSHRDSATRTRLFLASLPSSTHSMPELSGSSFGEVLRAKPWFEESPTPAELEGLAA CEGEYDYKYNTISPLGSGAFGFVWTAVEKECNKEVVVKFIKKEKVLEDCWIEDPKLGRVTLEIAILSKVD HANIIKVLDIFENQEFFQLVMEKHGSGMDLFAFIDHHPCLDEPLASFIFRQLVSAVGYLHSQGIIHRDIK DENIVIAEDFTIKLIDFGSAAYLERGKLFYTFCGTIEYCAPEVLIGNPYRGPELEMWSLGVTLYTLIFEE NPFCEVEETMEAVIHPPFLVSQELMSLLSGLLQPCPEQRTTLEKLIRDPWVTQPVNLASYTWEEVCRTNQ PESGLLSAASLEIGSRSPSEMAQREGLCGPPAPRETRGDQHCLHLKDPSLPVS TRTRPLEQKLISEEDLAANDILDYKDDDDKV
Tag	C-MYC/DDK
Predicted MW	151.7 kDa
Concentration	>0.05 µg/µL as determined by microplate BCA method
Purity	> 80% as determined by SDS-PAGE and Coomassie blue staining
Buffer	25 mM Tris-HCl, 100 mM glycine, pH 7.3, 10% glycerol
Note	For testing in cell culture applications, please filter before use. Note that you may experience some loss of protein during the filtration process.
Storage	Store at -80°C after receiving vials.
Stability	Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
Reference Data
RefSeq	NP_543126
Locus ID	269224
UniProt ID	Q8CEE6
Refseq Size	5119
Cytogenetics	1 D
Refseq ORF	4149
Synonyms	mKIAA0135
Summary	Serine/threonine-protein kinase involved in energy homeostasis and protein translation. Phosphorylates EEF1A1, GYS1, PDX1 and RPS6. Probably plays a role under changing environmental conditions (oxygen, glucose, nutrition), rather than under standard conditions. Acts as a sensor involved in energy homeostasis: regulates glycogen synthase synthesis by mediating phosphorylation of GYS1, leading to GYS1 inactivation. May be involved in glucose-stimulated insulin production in pancreas and regulation of glucagon secretion by glucose in alpha cells; however such data require additional evidences. May play a role in regulation of protein translation by phosphorylating EEF1A1, leading to increase translation efficiency. May also participate to respiratory regulation.[UniProtKB/Swiss-Prot Function]

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