Ranbp3 (NM_027933) Mouse Recombinant Protein

Specifications

Product Data
Species	Mouse
Expression Host	HEK293T
Expression cDNA Clone or AA Sequence	Protein Sequence (showhide) >MR218464 protein sequence Red=Cloning site Green=Tags(s) MADLANEEKPAVAPSVFVFQKDKGQKRSAGSSSPEAGEDSDHEDGNYCPPVKRERTSSLTHSEEKSSGFR LKPPTLIHGQAPSAGLPSQKPREQQRGVLRPAVLQAPQPKVLSQTVPSSGTNGVSMPADCTGPATSVSPE NLTQRSPSESAEETHTLEEKVPQKTPHGTSEEGHCEEEQAAPQAFVFGQNLRDRVKLMNENASVADVDSA AHPSSETPSATNYFLQYISSSADNATHSADNSTKFVFGQNMSERVLSPPKLNEANSDTSRETTHAQSGSE SSSQEAAPKKESLAESAAAYTKATAWTCLLEKVEVITGEEAESNVLQIQCKLFVFDKTSQSWVERGRGLL RLNDMASTDDGTLQSRLVMRTQGSLRLILNTKLWAQMQMDKASEKSIRITATDAEDQGVKVFLISASSKD TGQLYAALHHRILALRSRAEQEQEAKAPPPEPGATRATEEEDSDEDAVLAPSGVTGAGTGDEGDGQAPGS T TRTRPLEQKLISEEDLAANDILDYKDDDDKV
Tag	C-MYC/DDK
Predicted MW	52.6 kDa
Concentration	>0.05 µg/µL as determined by microplate BCA method
Purity	> 80% as determined by SDS-PAGE and Coomassie blue staining
Buffer	25 mM Tris-HCl, 100 mM glycine, pH 7.3, 10% glycerol
Note	For testing in cell culture applications, please filter before use. Note that you may experience some loss of protein during the filtration process.
Storage	Store at -80°C after receiving vials.
Stability	Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
Reference Data
RefSeq	NP_082209
Locus ID	71810
UniProt ID	Q9CT10
Refseq Size	2511
Cytogenetics	17 D
Refseq ORF	1473
Synonyms	2610024N24Rik; AA408221
Summary	Acts as a cofactor for XPO1/CRM1-mediated nuclear export, perhaps as export complex scaffolding protein. Bound to XPO1/CRM1, stabilizes the XPO1/CRM1-cargo interaction. In the absence of Ran-bound GTP prevents binding of XPO1/CRM1 to the nuclear pore complex. Binds to CHC1/RCC1 and increases the guanine nucleotide exchange activity of CHC1/RCC1. Recruits XPO1/CRM1 to CHC1/RCC1 in a Ran-dependent manner. Negative regulator of TGF-beta signaling through interaction with the R-SMAD proteins, SMAD2 and SMAD3, and mediating their nuclear export (By similarity).[UniProtKB/Swiss-Prot Function]

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