Tbc1d5 (NM_028162) Mouse Recombinant Protein

Specifications

Product Data
Species	Mouse
Expression Host	HEK293T
Expression cDNA Clone or AA Sequence	Protein Sequence (showhide) >MR210792 representing NM_028162 Red=Cloning site Green=Tags(s) MYKSVSETRHPLQSEEQEVGIDPLFSYSNKTRGDLSQNGRGSNSTLDTEGTFNSYMKEWEELFVNNNYLA TVRQKGINGQLRSSRFRSICWKLFLCVLPQDKSQWISKIKELRAWYSSIKEIHITNPRKAAGQQDLMINN PLSQDEGSLWNKFFQDKELRSMIEQDVKRTFPEMQFFQQENVRKILTDVLFCYARENEQLLYKQGMHELL APIIFTLHCDHQAFLHASESAQPSEEMKTLLNPEYLEHDAYAMFSQLMETAEPWFSTFEHDGQKGKETLM APIPFARPQDLGPTVAIVTKVNQIQDHLLKKHDIELYMHLNRLEIAPQIYGLRWVRLLFGREFPLQDLLV VWDALFADSLNLSLVDYVFTAMLLYIRDALISSNYQTCLGLLMHYPIIGDIHSLILKALFLRDPKRNPRP ATYQFHPNLDYYKARGADLMNKSRTNARGAPLNIHKVSNSLINFGRKLISPASAPGSMGGPVPGNNSSSS FSAAIPTRTSTEAPRHHLLQQQQQQQHQQQQQQQPQQQQQQHQQQQQQQRLMKSESMPVQLNKGQSSKTI SSSPSIESLPGGREFTGSPPPSATKKDSFFSNIARSRSHSKTMGRKESEEELEAQISFLQGQLNDLDAMC KYCAKVMDMHLVNIQDVVLQENLEKEDQILVSLAGLKQIKDILKGSLRFNQSQLEAGENEQITIADDHYC SSGQDQGSQVPRAAKQASSEMPGCTGGTTPDDFILVSKEDEGHRARGAFSGQAQPLLTLRSTSGKSRAPA CSPLLFSDPLMGPASASASSSNPSSSPDDDSSKESGFTIVSPLDI TRTRPLEQKLISEEDLAANDILDYKDDDDKV
Tag	C-MYC/DDK
Predicted MW	92.3 kDa
Concentration	>0.05 µg/µL as determined by microplate BCA method
Purity	> 80% as determined by SDS-PAGE and Coomassie blue staining
Buffer	25 mM Tris-HCl, 100 mM glycine, pH 7.3, 10% glycerol
Note	For testing in cell culture applications, please filter before use. Note that you may experience some loss of protein during the filtration process.
Storage	Store at -80°C after receiving vials.
Stability	Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
Reference Data
RefSeq	NP_082438
Locus ID	72238
UniProt ID	Q80XQ2
Refseq Size	5617
Cytogenetics	17 C
Refseq ORF	2445
Synonyms	1600014N05Rik
Summary	May act as a GTPase-activating protein for Rab family protein(s). May act as a GAP for RAB7A. Can displace RAB7A and retromer CSC subcomplex from the endosomal membrane to the cytosol; at least retromer displacement seems to require its catalytic activity. Required for retrograde transport of cargo proteins from endosomes to the trans-Golgi network (TGN); the function seems to require its catalytic activity. Involved in regulation of autophagy. May act as a molecular switch between endosomal and autophagosomal transport and is involved in reprogramming vesicle trafficking upon autophagy induction. Involved in the trafficking of ATG9A upon activation of autophagy. May regulate the recruitment of ATG9A-AP2-containing vesicles to autophagic membranes (By similarity).[UniProtKB/Swiss-Prot Function]

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