NNT1 (CLCF1) (NM_001166212) Human Recombinant Protein
CAT#: TP328765
Purified recombinant protein of Homo sapiens cardiotrophin-like cytokine factor 1 (CLCF1), transcript variant 2, 20 µg
View other "NNT1" proteins (6)
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Specifications
Product Data | |
Species | Human |
Expression Host | HEK293T |
Expression cDNA Clone or AA Sequence |
>RC228765 representing NM_001166212
Red=Cloning site Green=Tags(s) MDLRAGDSWGMLACLCTVLWHLPAVPALNRTGDPGPGPSIQKTYDLTRYLEHQLRSLAGTYLNYLGPPFN EPDFNPPRLGAETLPRATVDLEVWRSLNDKLRLTQNYEAYSHLLCYLRGLNRQAATAELRRSLAHFCTSL QGLLGSIAGVMAALGYPLPQPLPGTEPTWTPGPAHSDFLQKMDDFWLLKELQTWLWRSAKDFNRLKKKMQ PPAAAVTLHLGAHGF TRTRPLEQKLISEEDLAANDILDYKDDDDKV |
Tag | C-Myc/DDK |
Predicted MW | 23.9 kDa |
Concentration | >0.05 µg/µL as determined by microplate BCA method |
Purity | > 80% as determined by SDS-PAGE and Coomassie blue staining |
Buffer | 25 mM Tris-HCl, 100 mM glycine, pH 7.3, 10% glycerol |
Preparation | NULL or Add: Recombinant proteins was captured through anti-DDK affinity column followed by conventional chromatography steps. |
Note | For testing in cell culture applications, please filter before use. Note that you may experience some loss of protein during the filtration process. |
Storage | Store at -80°C. |
Stability | Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles. |
Reference Data | |
RefSeq | NP_001159684 |
Locus ID | 23529 |
UniProt ID | Q9UBD9 |
Cytogenetics | 11q13.2 |
Refseq ORF | 675 |
Synonyms | BSF-3; BSF3; CISS2; CLC; NNT-1; NNT1; NR6 |
Summary | This gene is a member of the glycoprotein (gp)130 cytokine family and encodes cardiotrophin-like cytokine factor 1 (CLCF1). CLCF1 forms a heterodimer complex with cytokine receptor-like factor 1 (CRLF1). This dimer competes with ciliary neurotrophic factor (CNTF) for binding to the ciliary neurotrophic factor receptor (CNTFR) complex, and activates the Jak-STAT signaling cascade. CLCF1 can be actively secreted from cells by forming a complex with soluble type I CRLF1 or soluble CNTFR. CLCF1 is a potent neurotrophic factor, B-cell stimulatory agent and neuroendocrine modulator of pituitary corticotroph function. Defects in CLCF1 cause cold-induced sweating syndrome 2 (CISS2). This syndrome is characterized by a profuse sweating after exposure to cold as well as congenital physical abnormalities of the head and spine. Alternative splicing results in multiple transcript variants encoding distinct isoforms.[provided by RefSeq, Oct 2009] |
Protein Families | Druggable Genome, Secreted Protein |
Protein Pathways | Cytokine-cytokine receptor interaction, Jak-STAT signaling pathway |
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Other Versions
SKU | Description | Size | Price |
---|---|---|---|
LC402229 | CLCF1 HEK293T cell transient overexpression lysate (as WB positive control) |
CNY 900.00 |
|
LC431793 | CLCF1 HEK293T cell transient overexpression lysate (as WB positive control) |
CNY 900.00 |
|
LY402229 | Transient overexpression lysate of cardiotrophin-like cytokine factor 1 (CLCF1), transcript variant 1 |
CNY 3,080.00 |
|
LY431793 | Transient overexpression lysate of cardiotrophin-like cytokine factor 1 (CLCF1), transcript variant 2 |
CNY 3,080.00 |
|
PH304427 | CLCF1 MS Standard C13 and N15-labeled recombinant protein (NP_037378) |
CNY 14,250.00 |
|
TP304427 | Recombinant protein of human cardiotrophin-like cytokine factor 1 (CLCF1), 20 µg |
CNY 2,900.00 |