CCM2 (NM_031443) Human Recombinant Protein
CAT＃: TP301418
Recombinant protein of human cerebral cavernous malformation 2 (CCM2), transcript variant 2, 20 µg
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Specifications
| Product Data | |
| Species | Human |
| Expression Host | HEK293T |
| Expression cDNA Clone or AA Sequence |
>RC201418 protein sequence
Red=Cloning site Green=Tags(s) MEEEGKKGKKPGIVSPFKRVFLKGEKSRDKKAHEKVTERRPLHTVVLSLPERVEPDRLLSDYIEKEVKYL GQLTSIPGYLNPSSRTEILHFIDNAKRAHQLPGHLTQEHDAVLSLSAYNVKLAWRDGEDIILRVPIHDIA AVSYVRDDAAHLVVLKTAQDPGISPSQSLCAESSRGLSAGSLSESAVGPVEACCLVILAAESKVAAEELC CLLGQVFQVVYTESTIDFLDRAIFDGASTPTHHLSLHSDDSSTKVDIKETYEVEASTFCFPESVDVGGAS PHSKTISESELSASATELLQDYMLTLRTKLSSQEIQQFAALLHEYRNGASIHEFCINLRQLYGDSRKFLL LGLRPFIPEKDSQHFENFLETIGVKDGRGIITDSFGRHRRALSTTSSSTTNGNRATGSSDDRSAPSEGDE WDRMISDISSDIEALGCSMDQDSA TRTRPLEQKLISEEDLAANDILDYKDDDDKV |
| Tag | C-Myc/DDK |
| Predicted MW | 48.7 kDa |
| Concentration | >0.05 µg/µL as determined by microplate BCA method |
| Purity | > 80% as determined by SDS-PAGE and Coomassie blue staining |
| Buffer | 25 mM Tris-HCl, 100 mM glycine, pH 7.3, 10% glycerol |
| Preparation | Recombinant protein was captured through anti-DDK affinity column followed by conventional chromatography steps. |
| Note | For testing in cell culture applications, please filter before use. Note that you may experience some loss of protein during the filtration process. |
| Storage | Store at -80°C. |
| Stability | Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles. |
| Reference Data | |
| RefSeq | NP_113631 |
| Locus ID | 83605 |
| UniProt ID | Q9BSQ5 |
| Refseq Size | 1904 |
| Cytogenetics | 7p13 |
| Refseq ORF | 1332 |
| Synonyms | C7orf22; OSM; PP10187 |
| Summary | This gene encodes a scaffold protein that functions in the stress-activated p38 Mitogen-activated protein kinase (MAPK) signaling cascade. The protein interacts with SMAD specific E3 ubiquitin protein ligase 1 (also known as SMURF1) via a phosphotyrosine binding domain to promote RhoA degradation. The protein is required for normal cytoskeletal structure, cell-cell interactions, and lumen formation in endothelial cells. Mutations in this gene result in cerebral cavernous malformations. Multiple transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Nov 2009] |
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Other Versions
| SKU | Description | Size | Price |
|---|---|---|---|
| LC410516 | CCM2 HEK293T cell transient overexpression lysate (as WB positive control) |
CNY 900.00 |
|
| LC422467 | CCM2 HEK293T cell transient overexpression lysate (as WB positive control) |
CNY 1470.00 |
|
| LC425504 | CCM2 HEK293T cell transient overexpression lysate (as WB positive control) |
CNY 900.00 |
|
| LC432927 | CCM2 HEK293T cell transient overexpression lysate (as WB positive control) |
CNY 900.00 |
|
| LC432976 | CCM2 HEK293T cell transient overexpression lysate (as WB positive control) |
CNY 900.00 |
|
| LY410516 | Transient overexpression lysate of cerebral cavernous malformation 2 (CCM2), transcript variant 2 |
CNY 3080.00 |
|
| LY422467 | Transient overexpression lysate of cerebral cavernous malformation 2 (CCM2), transcript variant 1 |
CNY 4840.00 |
|
| LY425504 | Transient overexpression lysate of cerebral cavernous malformation 2 (CCM2), transcript variant 1 |
CNY 3080.00 |
|
| LY432927 | Transient overexpression lysate of cerebral cavernous malformation 2 (CCM2), transcript variant 4 |
CNY 3080.00 |
|
| LY432976 | Transient overexpression lysate of cerebral cavernous malformation 2 (CCM2), transcript variant 3 |
CNY 3080.00 |
|
| PH301418 | CCM2 MS Standard C13 and N15-labeled recombinant protein (NP_113631) |
CNY 19520.00 |
