MDS1 (1-169, His-Tag) Human Protein

Specifications

Product Data
Species	Human
Expression Host	E. coli
Expression cDNA Clone or AA Sequence	Protein Sequence (showhide) MRSKGRA RKLATNNECV YGNYPEIPLE EMPDADGVAS TPSLNIQEPC SPATSSEAFT PKEGSPYKAP IYIPDDIPIP AEFELRESNM PGAGLGIWTK RKIEVGEKFG PYVGEQRSNL KDPSYGWEVH LPRSRRVSVH SWLYLGKRSS DVGIAFSQAD VYMPGLQCAF LS
Tag	His-Tag
Predicted MW	21.1 kDa (192aa)
Concentration	0.25mg/ml (determined by Bradford assay)
Purity	> 85% by SDS-PAGE
Buffer	Liquid in. 20mM Tris-HCl buffer (pH 8.0) containing , 10% glycerol, 0.4M urea
Preparation	Liquid purified protein
Applications	SDS-PAGE, Denatured
Storage	Can be stored at +2°C to +8°C for 1 week. For long term storage, aliquot and store at -20°C to -80C. Avoid repeated freezing and thawing cycles.
Stability	Shelf life: one year from despatch.
Reference Data
RefSeq	NP_004982.1
Locus ID	2122
UniProt ID	Q03112
Cytogenetics	3q26.2
Synonyms	MDS1 and EVI1 complex locus, myelodysplasia syndrome 1, ecotropic viral integration site 1, MDS1, EVI1, PRDM3, MDS1-EVI1
Summary	The protein encoded by this gene is a transcriptional regulator and oncoprotein that may be involved in hematopoiesis, apoptosis, development, and cell differentiation and proliferation. The encoded protein can interact with CTBP1, SMAD3, CREBBP, KAT2B, MAPK8, and MAPK9. This gene can undergo translocation with the AML1 gene, resulting in overexpression of this gene and the onset of leukemia. Several transcript variants encoding a few different isoforms have been found for this gene. [provided by RefSeq, Mar 2011]
Protein Families	Druggable Genome, Transcription Factors
Protein Pathways	Chronic myeloid leukemia, MAPK signaling pathway, Pathways in cancer

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