KAT2A / GCN5L2 (411-837, His-Tag) Human Protein

Specifications

Product Data
Species	Human
Expression Host	E. coli
Expression cDNA Clone or AA Sequence	Protein Sequence (showhide) MGGGSNSSLS LDSAGAEPMP GEKRTLPENL TLEDAKRLRV MGDIPMELVN EVMLTITDPA AMLGPETSLL SANAARDETA RLEERRGIIE FHVIGNSLTP KANRRVLLWL VGLQNVFSHQ LPRMPKEYIA RLVFDPKHKT LALIKDGRVI GGICFRMFPT QGFTEIVFCA VTSNEQVKGY GTHLMNHLKE YHIKHNILYF LTYADEYAIG YFKKQGFSKD IKVPKSRYLG YIKDYEGATL MECELNPRIP YTELSHIIKK QKEIIKKLIE RKQAQIRKVY PGLSCFKEGV RQIPVESVPG IRETGWKPLG KEKGKELKDP DQLYTTLKNL LAQIKSHPSA WPFMEPVKKS EAPDYYEVIR FPIDLKTMTE RLRSRYYVTR KLFVADLQRV IANCREYNPP DSEYCRCASA LEKFFYFKLK EGGLIDK
Tag	His-Tag
Predicted MW	51.1 kDa (447a) confirmed by MALDI-TOF
Concentration	0.25mg/ml (determined by Bradford assay)
Purity	> 85% by SDS-PAGE
Buffer	Liquid in. 20mM Tris-HCl buffer (pH 8.0) containing 5mM DTT, 40% glycerol, 200mM NaCl, 1mM EDTA
Preparation	Liquid purified protein
Applications	SDS-PAGE
Protein Description	Recombinant human GCN5L2 protein, fused to His-tag at N-terminus, was expressed in E.coli and purified by using conventional chromatography techniques.
Storage	Can be stored at +2°C to +8°C for 1 week. For long term storage, aliquot and store at -20°C to -80C. Avoid repeated freezing and thawing cycles.
Stability	Shelf life: one year from despatch.
Reference Data
RefSeq	NP_066564.2
Locus ID	2648
UniProt ID	Q92830
Cytogenetics	17q21.2
Synonyms	STAF97, PCAF-b, Lysine acetyltransferase 2A, Histone succinyltransferase KAT2A, Histone glutaryltransferase KAT2A, Histone acetyltransferase KAT2A, Histone acetyltransferase GCN5, General control of amino-acid synthesis 5-like 2, General control of amino acid synthesis protein 5-like 2, GCN5L2, GCN5
Summary	KAT2A, or GCN5, is a histone acetyltransferase (HAT) that functions primarily as a transcriptional activator. It also functions as a repressor of NF-kappa-B (see MIM 164011) by promoting ubiquitination of the NF-kappa-B subunit RELA (MIM 164014) in a HAT-independent manner (Mao et al., 2009 [PubMed 19339690]).[supplied by OMIM, Sep 2009]
Protein Families	Transcription Factors
Protein Pathways	Notch signaling pathway

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