CD54 / ICAM1 Human Protein

Specifications

Product Data
Species	Human
Expression Host	CHO
Expression cDNA Clone or AA Sequence	Protein Sequence (showhide) QTSVSPSKVI LPRGGSVLVT CSTSCDQPKL LGIETPLPKK ELLLPG NNRK VYELSNVQED SQPMCYSNCP DGQSTAKTFL TVYWTPERVE L APLPSWQPV GKNLTLRCQV EGGAPRANLT VVLLRGEKEL KREPAVG EPA EVTTTVLVRR DHHGANFSCR TELDLRPQGL ELFENTSAPY QL QTFVLPAT PPQLVSPRVL EVDTQGTVVC SLDGLFPVSE AQVHLALG DQ RLNPTVTYGN DSFSAKASVS VTAEDEGTQR LTCAVILGNQ SQE TLQTVTI YSFPAPNVIL TKPEVSEGTE VTVKCEAHPR AKVTLNGVP A QPLGPRAQLL LKATPEDNGR SFSCSATLEV AGQLIHKNQT RELR VLYGPR LDERDCPGNW TWPENSQQTP MCQAWGNPLP ELKCLKDGTF PLPIGESVTV TRDLEGTYLC RARSTQGEVT RKVTVNVLSP RYE
Predicted MW	72-80 kDa
Purity	>98% by SDS-PAGE and HPLC
Buffer	Presentation State: Purified State: Lyophilized purified protein Stabilizer: None
Preparation	Lyophilized purified protein
Protein Description	Recombinant human ICAM-1 is a 49.5 kDa glycoprotein comprising the extracellular domain (453 amino acid residues) of ICAM-1. Monomeric glycosylated ICAM-1 migrates at an apparent molecular weight of approximately 72.0-80.0 kDa by SDS-PAGE analysis under reducing conditions.
Storage	Store lyophilized at 2-8°C for 6 months or at -20°C long term. After reconstitution store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C long term. Avoid repeated freezing and thawing.
Stability	Shelf life: one year from despatch.
Bioactivity	Biological: ICAM-1 supported the adhesion of more than 50% PMA-stimulated HSB2 cells to plates coated at 25μg/ml ICAM-1 concentration
Endotoxin	< 0.1 ng per µg of ICAM-1
Reference Data
RefSeq	NP_000192
Locus ID	3383
UniProt ID	P05362
Cytogenetics	19p13.2
Synonyms	ICAM-1
Summary	This gene encodes a cell surface glycoprotein which is typically expressed on endothelial cells and cells of the immune system. It binds to integrins of type CD11a / CD18, or CD11b / CD18 and is also exploited by Rhinovirus as a receptor. [provided by RefSeq, Jul 2008]
Protein Families	Druggable Genome, ES Cell Differentiation/IPS, Transmembrane
Protein Pathways	Cell adhesion molecules (CAMs), Leukocyte transendothelial migration, Natural killer cell mediated cytotoxicity, Viral myocarditis

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