TCF3 / E2A (TCF3) (NM_001136139) Human Mass Spec Standard

CAT#: PH327647

TCF3 MS Standard C13 and N15-labeled recombinant protein (NP_001129611)



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CNY 19,520.00


货期*
4周

规格
    • 10 ug

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Specifications

Product Data
Description TCF3 MS Standard C13 and N15-labeled recombinant protein (NP_001129611)
Species Human
Expression Host HEK293
Expression cDNA Clone or AA Sequence RC227647
Predicted MW 67.1 kDa
Protein Sequence
Tag C-Myc/DDK
Purity > 80% as determined by SDS-PAGE and Coomassie blue staining
Concentration >0.05 µg/µL as determined by microplate BCA method
Labeling Method Labeled with [U- 13C6, 15N4]-L-Arginine and [U- 13C6, 15N2]-L-Lysine
Buffer 25 mM Tris-HCl, 100 mM glycine, pH 7.3
Reference Data
RefSeq NP_001129611
RefSeq ORF 1953
Synonyms AGM8; bHLHb21; E2A; E47; ITF1; p75; TCF-3; VDIR
Locus ID 6929
Cytogenetics 19p13.3
Summary This gene encodes a member of the E protein (class I) family of helix-loop-helix transcription factors. E proteins activate transcription by binding to regulatory E-box sequences on target genes as heterodimers or homodimers, and are inhibited by heterodimerization with inhibitor of DNA-binding (class IV) helix-loop-helix proteins. E proteins play a critical role in lymphopoiesis, and the encoded protein is required for B and T lymphocyte development. Deletion of this gene or diminished activity of the encoded protein may play a role in lymphoid malignancies. This gene is also involved in several chromosomal translocations that are associated with lymphoid malignancies including pre-B-cell acute lymphoblastic leukemia (t(1;19), with PBX1), childhood leukemia (t(19;19), with TFPT) and acute leukemia (t(12;19), with ZNF384). Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene, and a pseudogene of this gene is located on the short arm of chromosome 9. [provided by RefSeq, Sep 2011]
Protein Families Druggable Genome, ES Cell Differentiation/IPS, Induced pluripotent stem cells, Transcription Factors
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