CSK (NM_001127190) Human Mass Spec Standard
CAT＃: PH325740
CSK MS Standard C13 and N15-labeled recombinant protein (NP_001120662)
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CNY 19520.00
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Specifications
| Product Data | |
| Description | CSK MS Standard C13 and N15-labeled recombinant protein (NP_001120662) |
| Species | Human |
| Expression Host | HEK293 |
| Expression cDNA Clone or AA Sequence | RC225740 |
| Predicted MW | 50.7 kDa |
| Protein Sequence |
>RC225740 protein sequence
Red=Cloning site Green=Tags(s) MSAIQAAWPSGTECIAKYNFHGTAEQDLPFCKGDVLTIVAVTKDPNWYKAKNKVGREGIIPANYVQKREG VKAGTKLSLMPWFHGKITREQAERLLYPPETGLFLVRESTNYPGDYTLCVSCDGKVEHYRIMYHASKLSI DEEVYFENLMQLVEHYTSDADGLCTRLIKPKVMEGTVAAQDEFYRSGWALNMKELKLLQTIGKGEFGDVM LGDYRGNKVAVKCIKNDATAQAFLAEASVMTQLRHSNLVQLLGVIVEEKGGLYIVTEYMAKGSLVDYLRS RGRSVLGGDCLLKFSLDVCEAMEYLEGNNFVHRDLAARNVLVSEDNVAKVSDFGLTKEASSTQDTGKLPV KWTAPEALREKKFSTKSDVWSFGILLWEIYSFGRVPYPRIPLKDVVPRVEKGYKMDAPDGCPPAVYEVMK NCWHLDAAMRPSFLQLREQLEHIKTHELHL TRTRPLEQKLISEEDLAANDILDYKDDDDKV |
| Tag | C-Myc/DDK |
| Purity | > 80% as determined by SDS-PAGE and Coomassie blue staining |
| Concentration | >0.05 µg/µL as determined by microplate BCA method |
| Labeling Method | Labeled with [U- 13C6, 15N4]-L-Arginine and [U- 13C6, 15N2]-L-Lysine |
| Buffer | 25 mM Tris-HCl, 100 mM glycine, pH 7.3 |
| Reference Data | |
| RefSeq | NP_001120662 |
| RefSeq Size | 2236 |
| RefSeq ORF | 1350 |
| Locus ID | 1445 |
| Cytogenetics | 15q24.1 |
| Summary | The protein encoded by this gene is involved in multiple pathways, including the regulation of Src family kinases. It plays an important role in T-cell activation through its association with the protein encoded by the protein tyrosine phosphatase, non-receptor type 22 (PTPN22) gene. This protein also phosphorylates C-terminal tyrosine residues on multiple substrates, including the protein encoded by the SRC proto-oncogene, non-receptor tyrosine kinase gene. Phosphorylation suppresses the kinase activity of the Src family tyrosine kinases. An intronic polymorphism (rs34933034) in this gene has been found to affect B-cell activation and is associated with systemic lupus erythematosus (SLE). Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2017] |
| Protein Families | Druggable Genome, Protein Kinase |
| Protein Pathways | Chemokine signaling pathway, Epithelial cell signaling in Helicobacter pylori infection, Neurotrophin signaling pathway, Regulation of actin cytoskeleton |
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Other Versions
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| LC401395 | CSK HEK293T cell transient overexpression lysate (as WB positive control) |
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| LC426695 | CSK HEK293T cell transient overexpression lysate (as WB positive control) |
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| LY401395 | Transient overexpression lysate of c-src tyrosine kinase (CSK), transcript variant 1 |
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| LY426695 | Transient overexpression lysate of c-src tyrosine kinase (CSK), transcript variant 2 |
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| PH310758 | CSK MS Standard C13 and N15-labeled recombinant protein (NP_004374) |
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| TP310758 | Recombinant protein of human c-src tyrosine kinase (CSK), transcript variant 1, 20 µg |
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| TP325740 | Recombinant protein of human c-src tyrosine kinase (CSK), transcript variant 2, 20 µg |
CNY 2900.00 |
Recombinant protein of human c-src tyrosine kinase (CSK), transcript variant 2, 100 µg
