Dematin (DMTN) (NM_001114135) Human Mass Spec Standard

CAT#: PH325632

EPB49 MS Standard C13 and N15-labeled recombinant protein (NP_001107607)



  View other "Dematin" proteins (14)

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CNY 19,520.00


货期*
4周

规格
    • 10 ug

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Specifications

Product Data
Description EPB49 MS Standard C13 and N15-labeled recombinant protein (NP_001107607)
Species Human
Expression Host HEK293
Expression cDNA Clone or AA Sequence RC225632
Predicted MW 45.5 kDa
Protein Sequence
Tag C-Myc/DDK
Purity > 80% as determined by SDS-PAGE and Coomassie blue staining
Concentration >0.05 µg/µL as determined by microplate BCA method
Labeling Method Labeled with [U- 13C6, 15N4]-L-Arginine and [U- 13C6, 15N2]-L-Lysine
Buffer 25 mM Tris-HCl, 100 mM glycine, pH 7.3
Reference Data
RefSeq NP_001107607
RefSeq Size 2604
RefSeq ORF 1215
Synonyms DMT; EPB49
Locus ID 2039
Cytogenetics 8p21.3
Summary The protein encoded by this gene is an actin binding and bundling protein that plays a structural role in erythrocytes, by stabilizing and attaching the spectrin/actin cytoskeleton to the erythrocyte membrane in a phosphorylation-dependent manner. This protein contains a core domain in the N-terminus, and a headpiece domain in the C-terminus that binds F-actin. When purified from erythrocytes, this protein exists as a trimer composed of two 48 kDa polypeptides and a 52 kDa polypeptide. The different subunits arise from alternative splicing in the 3' coding region, where the headpiece domain is located. Disruption of this gene has been correlated with the autosomal dominant Marie Unna hereditary hypotrichosis disease, while loss of heterozygosity of this gene is thought to play a role in prostate cancer progression. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Nov 2014]
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