IL5RA (NM_175727) Human Mass Spec Standard

CAT#: PH322553

IL5RA MS Standard C13 and N15-labeled recombinant protein (NP_783854)



  View other "IL5RA" proteins (13)

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CNY 14,250.00


货期*
5周

规格
    • 10 ug

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Transient overexpression lysate of interleukin 5 receptor, alpha (IL5RA), transcript variant 6
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Specifications

Product Data
Description IL5RA MS Standard C13 and N15-labeled recombinant protein (NP_783854)
Species Human
Expression Host HEK293
Expression cDNA Clone or AA Sequence RC222553
Predicted MW 37.5 kDa
Protein Sequence
Tag C-Myc/DDK
Purity > 80% as determined by SDS-PAGE and Coomassie blue staining
Concentration >0.05 µg/µL as determined by microplate BCA method
Labeling Method Labeled with [U- 13C6, 15N4]-L-Arginine and [U- 13C6, 15N2]-L-Lysine
Buffer 25 mM Tris-HCl, 100 mM glycine, pH 7.3
Reference Data
RefSeq NP_783854
RefSeq Size 1956
RefSeq ORF 999
Synonyms CD125; CDw125; HSIL5R3; IL5R
Locus ID 3568
Cytogenetics 3p26.2
Summary The protein encoded by this gene is an interleukin 5 specific subunit of a heterodimeric cytokine receptor. The receptor is comprised of a ligand specific alpha subunit and a signal transducing beta subunit shared by the receptors for interleukin 3 (IL3), colony stimulating factor 2 (CSF2/GM-CSF), and interleukin 5 (IL5). The binding of this protein to IL5 depends on the beta subunit. The beta subunit is activated by the ligand binding, and is required for the biological activities of IL5. This protein has been found to interact with syndecan binding protein (syntenin), which is required for IL5 mediated activation of the transcription factor SOX4. Several alternatively spliced transcript variants encoding four distinct isoforms have been reported. [provided by RefSeq, Jul 2011]
Protein Families Druggable Genome, Transmembrane
Protein Pathways Cytokine-cytokine receptor interaction, Hematopoietic cell lineage, Jak-STAT signaling pathway
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