Osteocalcin (BGLAP) (NM_199173) Human Mass Spec Standard

Specifications

Product Data
Description	BGLAP MS Standard C13 and N15-labeled recombinant protein (NP_954642)
Species	Human
Expression Host	HEK293
Expression cDNA Clone or AA Sequence	RC220555
Predicted MW	8.7 kDa
Protein Sequence	Sequence Link (showhide) >RC220555 representing NM_199173 Red=Cloning site Green=Tags(s) MRALTLLALLALAALCIAGQAGAKPSGAESSKGAAFVSKQEGSEVVKRPRRYLYQWLGAPVPYPDPLEPR REVCELNPDCDELADHIGFQEAYRRFYGPV TRTRPLEQKLISEEDLAANDILDYKDDDDKV
Tag	C-Myc/DDK
Purity	> 80% as determined by SDS-PAGE and Coomassie blue staining
Concentration	>0.05 µg/µL as determined by microplate BCA method
Labeling Method	Labeled with [U- 13C6, 15N4]-L-Arginine and [U- 13C6, 15N2]-L-Lysine
Buffer	25 mM Tris-HCl, 100 mM glycine, pH 7.3
Reference Data
RefSeq	NP_954642
RefSeq Size	498
RefSeq ORF	300
Synonyms	BGP; OC; OCN
Locus ID	632
Cytogenetics	1q22
Summary	This gene encodes a highly abundant bone protein secreted by osteoblasts that regulates bone remodeling and energy metabolism. The encoded protein contains a Gla (gamma carboxyglutamate) domain, which functions in binding to calcium and hydroxyapatite, the mineral component of bone. Serum osteocalcin levels may be negatively correlated with metabolic syndrome. Read-through transcription exists between this gene and the neighboring upstream gene, PMF1 (polyamine-modulated factor 1), but the encoded protein only shows sequence identity with the upstream gene product. [provided by RefSeq, Jun 2015]
Protein Families	ES Cell Differentiation/IPS, Secreted Protein

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