GABA A Receptor alpha 5 (GABRA5) (NM_000810) Human Mass Spec Standard

Specifications

Product Data
Description	GABRA5 MS Standard C13 and N15-labeled recombinant protein (NP_000801)
Species	Human
Expression Host	HEK293
Expression cDNA Clone or AA Sequence	RC216541
Predicted MW	52.1 kDa
Protein Sequence	Sequence Link (showhide) >Peptide sequence encoded by RC216541 Blue=ORF Red=Cloning site Green=Tag(s) MDNGMFSGFIMIKNLLLFCISMNLSSHFGFSQMPTSSVKDETNDNITIFTRILDGLLDGYDNRLRPGLG ERITQVRTDIYVTSFGPVSDTEMEYTIDVFFRQSWKDERLRFKGPMQRLPLNNLLASKIWTPDTFFHNG KKSIAHNMTTPNKLLRLEDDGTLLYTMRLTISAECPMQLEDFPMDAHACPLKFGSYAYPNSEVVYVWTN GSTKSVVVAEDGSRLNQYHLMGQTVGTENISTSTGEYTIMTAHFHLKRKIGYFVIQTYLPCIMTVILSQ VSFWLNRESVPARTVFGVTTVLTMTTLSISARNSLPKVAYATAMDWFIAVCYAFVFSALIEFATVNYFT KRGWAWDGKKALEAAKIKKKREVILNKSTNAFTTGKMSHPPNIPKEQTPAGTSNTTSVSVKPSEEKTSE SKKTYNSISKIDKMSRIVFPVLFGTFNLVYWATYLNREPVIKGAASPK SGPTRTRPLEQKLISEEDLAANDILDYKDDDDKV Recombinant protein using RC216541 also available, TP316541M
Tag	C-Myc/DDK
Purity	> 80% as determined by SDS-PAGE and Coomassie blue staining
Concentration	>0.05 µg/µL as determined by microplate BCA method
Labeling Method	Labeled with [U- 13C6, 15N4]-L-Arginine and [U- 13C6, 15N2]-L-Lysine
Buffer	25 mM Tris-HCl, 100 mM glycine, pH 7.3
Reference Data
RefSeq	NP_000801
RefSeq Size	2352
RefSeq ORF	1386
Synonyms	DEE79; EIEE79
Locus ID	2558
Cytogenetics	15q12
Summary	GABA is the major inhibitory neurotransmitter in the mammalian brain where it acts at GABA-A receptors, which are ligand-gated chloride channels. Chloride conductance of these channels can be modulated by agents such as benzodiazepines that bind to the GABA-A receptor. At least 16 distinct subunits of GABA-A receptors have been identified. Transcript variants utilizing three different alternative non-coding first exons have been described. [provided by RefSeq, Jul 2008]
Protein Families	Druggable Genome, Ion Channels: Cys-loop Receptors, Transmembrane
Protein Pathways	Neuroactive ligand-receptor interaction

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