PDE6H (NM_006205) Human Mass Spec Standard

Specifications

Product Data
Description	PDE6H MS Standard C13 and N15-labeled recombinant protein (NP_006196)
Species	Human
Expression Host	HEK293
Expression cDNA Clone or AA Sequence	RC210215
Predicted MW	9.1 kDa
Protein Sequence	Sequence Link (showhide) >RC210215 protein sequence Red=Cloning site Green=Tags(s) MSDNTTLPAPASNQGPTTPRKGPPKFKQRQTRQFKSKPPKKGVKGFGDDIPGMEGLGTDITVICPWEAFS HLELHELAQFGII TRTRPLEQKLISEEDLAANDILDYKDDDDKV
Tag	C-Myc/DDK
Purity	> 80% as determined by SDS-PAGE and Coomassie blue staining
Concentration	>0.05 µg/µL as determined by microplate BCA method
Labeling Method	Labeled with [U- 13C6, 15N4]-L-Arginine and [U- 13C6, 15N2]-L-Lysine
Buffer	25 mM Tris-HCl, 100 mM glycine, pH 7.3
Reference Data
RefSeq	NP_006196
RefSeq Size	763
RefSeq ORF	249
Synonyms	ACHM6; RCD3
Locus ID	5149
Cytogenetics	12p12.3
Summary	This gene encodes the inhibitory (or gamma) subunit of the cone-specific cGMP phosphodiesterase, which is a tetramer composed of two catalytic chains (alpha and beta), and two inhibitory chains (gamma). It is specifically expressed in the retina, and is involved in the transmission and amplification of the visual signal. Mutations in this gene are associated with retinal cone dystrophy type 3A (RCD3A). [provided by RefSeq, Mar 2010]
Protein Pathways	Progesterone-mediated oocyte maturation, Purine metabolism

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