NRARP (NM_001004354) Human Mass Spec Standard

Specifications

Product Data
Description	NRARP MS Standard C13 and N15-labeled recombinant protein (NP_001004354)
Species	Human
Expression Host	HEK293
Expression cDNA Clone or AA Sequence	RC208806
Predicted MW	12.5 kDa
Protein Sequence	Sequence Link (showhide) >RC208806 protein sequence Red=Cloning site Green=Tags(s) MSQAELSTCSAPQTQRIFQEAVRKGNTQELQSLLQNMTNCEFNVNSFGPEGQTALHQSVIDGNLELVKLL VKFGADIRLANRDGWSALHIAAFGGHQDIVLYLITKAKYAASGR TRTRPLEQKLISEEDLAANDILDYKDDDDKV
Tag	C-Myc/DDK
Purity	> 80% as determined by SDS-PAGE and Coomassie blue staining
Concentration	>0.05 µg/µL as determined by microplate BCA method
Labeling Method	Labeled with [U- 13C6, 15N4]-L-Arginine and [U- 13C6, 15N2]-L-Lysine
Buffer	25 mM Tris-HCl, 100 mM glycine, pH 7.3
Reference Data
RefSeq	NP_001004354
RefSeq Size	2639
RefSeq ORF	342
Locus ID	441478
Cytogenetics	9q34.3
Summary	Downstream effector of Notch signaling. Involved in the regulation of liver cancer cells self-renewal (PubMed:25985737). Involved in angiogenesis acting downstream of Notch at branch points to regulate vascular density. Proposed to integrate endothelial Notch and Wnt signaling to control stalk cell proliferation and to stablilize new endothelial connections during angiogenesis (PubMed:19154719). During somitogenesis involved in maintenance of proper somite segmentation and proper numbers of somites and vertebrae. Required for proper anterior-posterior somite patterning. Proposed to function in a negative feedback loop to destabilize Notch 1 intracellular domain (NICD) and downregulate the Notch signal, preventing expansion of the Notch signal into the anterior somite domain (By similarity).[UniProtKB/Swiss-Prot Function]

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