C15orf38 (ARPIN) (NM_182616) Human Mass Spec Standard

Specifications

Product Data
Description	C15orf38 MS Standard C13 and N15-labeled recombinant protein (NP_872422)
Species	Human
Expression Host	HEK293
Expression cDNA Clone or AA Sequence	RC208793
Predicted MW	24.9 kDa
Protein Sequence	Sequence Link (showhide) >RC208793 protein sequence Red=Cloning site Green=Tags(s) MSRIYHDGALRNKAVQSVRLPGAWDPAAHQGGNGVLLEGELIDVSRHSILDTHGRKERYYVLYIRPSHIH RRKFDAKGNEIEPNFSATRKVNTGFLMSSYKVEAKGDTDRLTPEALKGLVNKPELLALTESLTPDHTVAF WMPESEMEVMELELGAGVRLKTRGDGPFLDSLAKLEAGTVTKCNFTGDGKTGASWTDNIMAQKCSKGAAA EIREQGDGAEDEEWDD TRTRPLEQKLISEEDLAANDILDYKDDDDKV
Tag	C-Myc/DDK
Purity	> 80% as determined by SDS-PAGE and Coomassie blue staining
Concentration	>0.05 µg/µL as determined by microplate BCA method
Labeling Method	Labeled with [U- 13C6, 15N4]-L-Arginine and [U- 13C6, 15N2]-L-Lysine
Buffer	25 mM Tris-HCl, 100 mM glycine, pH 7.3
Reference Data
RefSeq	NP_872422
RefSeq Size	6114
RefSeq ORF	678
Synonyms	C15orf38
Locus ID	348110
Cytogenetics	15q26.1
Summary	Regulates actin polymerization by inhibiting the actin-nucleating activity of the Arp2/3 complex; the function is competetive with nucleation promoting factors. Participates in an incoherent feedforward loop at the lamellipodium tip where it inhibits the ARP2/2 complex in response to Rac signaling and where Rac also stimulates actin polymerization through the WAVE complex. Involved in steering cell migration by controlling its directional persistence.[UniProtKB/Swiss-Prot Function]

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