UBE2L3 (NM_003347) Human Mass Spec Standard

Specifications

Product Data
Description	UBE2L3 MS Standard C13 and N15-labeled recombinant protein (NP_003338)
Species	Human
Expression Host	HEK293
Expression cDNA Clone or AA Sequence	RC208780
Predicted MW	17.9 kDa
Protein Sequence	Sequence Link (showhide) >RC208780 protein sequence Red=Cloning site Green=Tags(s) MAASRRLMKELEEIRKCGMKNFRNIQVDEANLLTWQGLIVPDNPPYDKGAFRIEINFPAEYPFKPPKITF KTKIYHPNIDEKGQVCLPVISAENWKPATKTDQVIQSLIALVNDPQPEHPLRADLAEEYSKDRKKFCKNA EEFTKKYGEKRPVD TRTRPLEQKLISEEDLAANDILDYKDDDDKV
Tag	C-Myc/DDK
Purity	> 80% as determined by SDS-PAGE and Coomassie blue staining
Concentration	>0.05 µg/µL as determined by microplate BCA method
Labeling Method	Labeled with [U- 13C6, 15N4]-L-Arginine and [U- 13C6, 15N2]-L-Lysine
Buffer	25 mM Tris-HCl, 100 mM glycine, pH 7.3
Reference Data
RefSeq	NP_003338
RefSeq Size	3028
RefSeq ORF	462
Synonyms	E2-F1; L-UBC; UBCH7; UbcM4
Locus ID	7332
Cytogenetics	22q11.21
Summary	The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes (E1s), ubiquitin-conjugating enzymes (E2s) and ubiquitin-protein ligases (E3s). This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. This enzyme is demonstrated to participate in the ubiquitination of p53, c-Fos, and the NF-kB precursor p105 in vitro. Several alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Sep 2009]
Protein Pathways	Parkinson's disease, Ubiquitin mediated proteolysis

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