SAP18 (NM_005870) Human Mass Spec Standard

Specifications

Product Data
Description	SAP18 MS Standard C13 and N15-labeled recombinant protein (NP_005861)
Species	Human
Expression Host	HEK293
Expression cDNA Clone or AA Sequence	RC205607
Predicted MW	17.6 kDa
Protein Sequence	Sequence Link (showhide) >RC205607 protein sequence Red=Cloning site Green=Tags(s) MAVESRVTQEEIKKEPEKPIDREKTCPLLLRVFTTNNGRHHRMDEFSRGNVPSSELQIYTWMDATLKELT SLVKEVYPEARKKGTHFNFAIVFTDVKRPGYRVKEIGSTMSGRKGTDDSMTLQSQKFQIGDYLDIAITPP NRAPPTSGRMRPY TRTRPLEQKLISEEDLAANDILDYKDDDDKV
Tag	C-Myc/DDK
Purity	> 80% as determined by SDS-PAGE and Coomassie blue staining
Concentration	>0.05 µg/µL as determined by microplate BCA method
Labeling Method	Labeled with [U- 13C6, 15N4]-L-Arginine and [U- 13C6, 15N2]-L-Lysine
Buffer	25 mM Tris-HCl, 100 mM glycine, pH 7.3
Reference Data
RefSeq	NP_005861
RefSeq Size	2318
RefSeq ORF	459
Synonyms	2HOR0202; SAP18P
Locus ID	10284
Cytogenetics	13q12.11
Summary	Histone acetylation plays a key role in the regulation of eukaryotic gene expression. Histone acetylation and deacetylation are catalyzed by multisubunit complexes. The protein encoded by this gene is a component of the histone deacetylase complex, which includes SIN3, SAP30, HDAC1, HDAC2, RbAp46, RbAp48, and other polypeptides. This protein directly interacts with SIN3 and enhances SIN3-mediated transcriptional repression when tethered to the promoter. A pseudogene has been identified on chromosome 2. [provided by RefSeq, Dec 2008]
Protein Families	Druggable Genome, Transcription Factors

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