Frataxin (FXN) (NM_000144) Human Mass Spec Standard

Specifications

Product Data
Description	FXN MS Standard C13 and N15-labeled recombinant protein (NP_000135)
Species	Human
Expression Host	HEK293
Expression cDNA Clone or AA Sequence	RC204880
Predicted MW	23.1 kDa
Protein Sequence	Sequence Link (showhide) >RC204880 protein sequence Red=Cloning site Green=Tags(s) MWTLGRRAVAGLLASPSPAQAQTLTRVPRPAELAPLCGRRGLRTDIDATCTPRRASSNQRGLNQIWNVKK QSVYLMNLRKSGTLGHPGSLDETTYERLAEETLDSLAEFFEDLADKPYTFEDYDVSFGSGVLTVKLGGDL GTYVINKQTPNKQIWLSSPSSGPKRYDWTGKNWVYSHDGVSLHELLAAELTKALKTKLDLSSLAYSGKDA TRTRPLEQKLISEEDLAANDILDYKDDDDKV
Tag	C-Myc/DDK
Purity	> 80% as determined by SDS-PAGE and Coomassie blue staining
Concentration	>0.05 µg/µL as determined by microplate BCA method
Labeling Method	Labeled with [U- 13C6, 15N4]-L-Arginine and [U- 13C6, 15N2]-L-Lysine
Buffer	25 mM Tris-HCl, 100 mM glycine, pH 7.3
Reference Data
RefSeq	NP_000135
RefSeq Size	7168
RefSeq ORF	630
Synonyms	CyaY; FA; FARR; FRDA; X25
Locus ID	2395
Cytogenetics	9q21.11
Summary	This nuclear gene encodes a mitochondrial protein which belongs to the FRATAXIN family. The protein functions in regulating mitochondrial iron transport and respiration. The expansion of intronic trinucleotide repeat GAA from 8-33 repeats to >90 repeats results in Friedreich ataxia. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2016]
Protein Families	Druggable Genome

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