CDK2AP1 (NM_004642) Human Mass Spec Standard

CAT#: PH304442

CDK2AP1 MS Standard C13 and N15-labeled recombinant protein (NP_004633)



  View other "CDK2AP1" proteins (3)

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CNY 19,520.00


货期*
4周

规格
    • 10 ug

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经常一起买 (2)
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Rabbit Polyclonal CDK2AP1 Antibody
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Specifications

Product Data
Description CDK2AP1 MS Standard C13 and N15-labeled recombinant protein (NP_004633)
Species Human
Expression Host HEK293
Expression cDNA Clone or AA Sequence RC204442
Predicted MW 12.4 kDa
Protein Sequence
Tag C-Myc/DDK
Purity > 80% as determined by SDS-PAGE and Coomassie blue staining
Concentration >0.05 µg/µL as determined by microplate BCA method
Labeling Method Labeled with [U- 13C6, 15N4]-L-Arginine and [U- 13C6, 15N2]-L-Lysine
Buffer 25 mM Tris-HCl, 100 mM glycine, pH 7.3
Reference Data
RefSeq NP_004633
RefSeq Size 1655
RefSeq ORF 345
Synonyms doc-1; DOC1; DORC1; p12DOC-1; ST19
Locus ID 8099
Cytogenetics 12q24.31
Summary The protein encoded by this gene is a cyclin-dependent kinase 2 (CDK2) -associated protein which is thought to negatively regulate CDK2 activity by sequestering monomeric CDK2, and targeting CDK2 for proteolysis. This protein was found to also interact with DNA polymerase alpha/primase and mediate the phosphorylation of the large p180 subunit, which suggests a regulatory role in DNA replication during the S-phase of the cell cycle. This protein also forms a core subunit of the nucleosome remodeling and histone deacetylation (NURD) complex that epigenetically regulates embryonic stem cell differentiation. This gene thus plays a role in both cell-cycle and epigenetic regulation. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2012]
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