Kallikrein 7 (KLK7) (NM_005046) Human Mass Spec Standard

Specifications

Product Data
Description	KLK7 MS Standard C13 and N15-labeled recombinant protein (NP_005037)
Species	Human
Expression Host	HEK293
Expression cDNA Clone or AA Sequence	RC204423
Predicted MW	27.6 kDa
Protein Sequence	Sequence Link (showhide) >RC204423 protein sequence Red=Cloning site Green=Tags(s) MARSLLLPLQILLLSLALETAGEEAQGDKIIDGAPCARGSHPWQVALLSGNQLHCGGVLVNERWVLTAAH CKMNEYTVHLGSDTLGDRRAQRIKASKSFRHPGYSTQTHVNDLMLVKLNSQARLSSMVKKVRLPSRCEPP GTTCTVSGWGTTTSPDVTFPSDLMCVDVKLISPQDCTKVYKDLLENSMLCAGIPDSKKNACNGDSGGPLV CRGTLQGLVSWGTFPWGQPNDPGVYTQVCKFTKWINDTMKKHR TRTRPLEQKLISEEDLAANDILDYKDDDDKV
Tag	C-Myc/DDK
Purity	> 80% as determined by SDS-PAGE and Coomassie blue staining
Concentration	>0.05 µg/µL as determined by microplate BCA method
Labeling Method	Labeled with [U- 13C6, 15N4]-L-Arginine and [U- 13C6, 15N2]-L-Lysine
Buffer	25 mM Tris-HCl, 100 mM glycine, pH 7.3
Reference Data
RefSeq	NP_005037
RefSeq Size	2104
RefSeq ORF	759
Synonyms	hK7; PRSS6; SCCE
Locus ID	5650
Cytogenetics	19q13.41
Summary	This gene encodes a member of the kallikrein subfamily of serine proteases. These enzymes have diverse physiological functions and many kallikrein genes are biomarkers for cancer. The encoded protein has chymotrypsin-like activity and plays a role in the proteolysis of intercellular cohesive structures that precedes desquamation, the shedding of the outermost layer of the epidermis. The encoded protein may play a role in cancer invasion and metastasis, and increased expression of this gene is associated with unfavorable prognosis and progression of several types of cancer. Polymorphisms in this gene may play a role in the development of atopic dermatitis. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene, which is one of fifteen kallikrein subfamily members located in a gene cluster on chromosome 19. [provided by RefSeq, May 2011]
Protein Families	Druggable Genome, Secreted Protein

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