Inosine triphosphate pyrophosphatase (ITPA) (NM_033453) Human Mass Spec Standard

Specifications

Product Data
Description	ITPA MS Standard C13 and N15-labeled recombinant protein (NP_258412)
Species	Human
Expression Host	HEK293
Expression cDNA Clone or AA Sequence	RC204021
Predicted MW	21.4 kDa
Protein Sequence	Sequence Link (showhide) >RC204021 protein sequence Red=Cloning site Green=Tags(s) MAASLVGKKIVFVTGNAKKLEEVVQILGDKFPCTLVAQKIDLPEYQGEPDEISIQKCQEAVRQVQGPVLV EDTCLCFNALGGLPGPYIKWFLEKLKPEGLHQLLAGFEDKSAYALCTFALSTGDPSQPVRLFRGRTSGRI VAPRGCQDFGWDPCFQPDGYEQTYAEMPKAEKNAVSHRFRALLELQEYFGSLAA TRTRPLEQKLISEEDLAANDILDYKDDDDKV
Tag	C-Myc/DDK
Purity	> 80% as determined by SDS-PAGE and Coomassie blue staining
Concentration	>0.05 µg/µL as determined by microplate BCA method
Labeling Method	Labeled with [U- 13C6, 15N4]-L-Arginine and [U- 13C6, 15N2]-L-Lysine
Buffer	25 mM Tris-HCl, 100 mM glycine, pH 7.3
Reference Data
RefSeq	NP_258412
RefSeq Size	1202
RefSeq ORF	582
Synonyms	C20orf37; DEE35; dJ794I6.3; HLC14-06-P; ITPase; My049; NTPase
Locus ID	3704
Cytogenetics	20p13
Summary	This gene encodes an inosine triphosphate pyrophosphohydrolase. The encoded protein hydrolyzes inosine triphosphate and deoxyinosine triphosphate to the monophosphate nucleotide and diphosphate. This protein, which is a member of the HAM1 NTPase protein family, is found in the cytoplasm and acts as a homodimer. Defects in the encoded protein can result in inosine triphosphate pyrophosphorylase deficiency which causes an accumulation of ITP in red blood cells. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jun 2012]
Protein Families	Druggable Genome
Protein Pathways	Drug metabolism - other enzymes, Metabolic pathways, Purine metabolism, Pyrimidine metabolism

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