Angiotensinogen (AGT) (NM_000029) Human Mass Spec Standard

CAT#: PH303768

AGT MS Standard C13 and N15-labeled recombinant protein (NP_000020)



  View other "Angiotensinogen" proteins (4)

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CNY 19,520.00


货期*
4周

规格
    • 10 ug

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经常一起买 (2)
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Specifications

Product Data
Description AGT MS Standard C13 and N15-labeled recombinant protein (NP_000020)
Species Human
Expression Host HEK293
Expression cDNA Clone or AA Sequence RC203768
Predicted MW 53.1 kDa
Protein Sequence
Tag C-Myc/DDK
Purity > 80% as determined by SDS-PAGE and Coomassie blue staining
Concentration >0.05 µg/µL as determined by microplate BCA method
Labeling Method Labeled with [U- 13C6, 15N4]-L-Arginine and [U- 13C6, 15N2]-L-Lysine
Buffer 25 mM Tris-HCl, 100 mM glycine, pH 7.3
Reference Data
RefSeq NP_000020
RefSeq Size 2587
RefSeq ORF 1455
Synonyms ANHU; hFLT1; SERPINA8
Locus ID 183
Cytogenetics 1q42.2
Summary The protein encoded by this gene, pre-angiotensinogen or angiotensinogen precursor, is expressed in the liver and is cleaved by the enzyme renin in response to lowered blood pressure. The resulting product, angiotensin I, is then cleaved by angiotensin converting enzyme (ACE) to generate the physiologically active enzyme angiotensin II. The protein is involved in maintaining blood pressure, body fluid and electrolyte homeostasis, and in the pathogenesis of essential hypertension and preeclampsia. Mutations in this gene are associated with susceptibility to essential hypertension, and can cause renal tubular dysgenesis, a severe disorder of renal tubular development. Defects in this gene have also been associated with non-familial structural atrial fibrillation, and inflammatory bowel disease. [provided by RefSeq, Nov 2019]
Protein Families Druggable Genome, Secreted Protein
Protein Pathways Renin-angiotensin system
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