CIAO2A (NM_032231) Human Mass Spec Standard

Specifications

Product Data
Description	FAM96A MS Standard C13 and N15-labeled recombinant protein (NP_115607)
Species	Human
Expression Host	HEK293
Expression cDNA Clone or AA Sequence	RC203357
Predicted MW	18.4 kDa
Protein Sequence	Sequence Link (showhide) >RC203357 protein sequence Red=Cloning site Green=Tags(s) MQRVSGLLSWTLSRVLWLSGLSEPGAARQPRIMEEKALEVYDLIRTIRDPEKPNTLEELEVVSESCVEVQ EINEEEYLVIIRFTPTVPHCSLATLIGLCLRVKLQRCLPFKHKLEIYISEGTHSTEEDINKQINDKERVA AAMENPNLREIVEQCVLEPD TRTRPLEQKLISEEDLAANDILDYKDDDDKV
Tag	C-Myc/DDK
Purity	> 80% as determined by SDS-PAGE and Coomassie blue staining
Concentration	>0.05 µg/µL as determined by microplate BCA method
Labeling Method	Labeled with [U- 13C6, 15N4]-L-Arginine and [U- 13C6, 15N2]-L-Lysine
Buffer	25 mM Tris-HCl, 100 mM glycine, pH 7.3
Reference Data
RefSeq	NP_115607
RefSeq Size	1114
RefSeq ORF	480
Synonyms	CIA2A; FAM96A
Locus ID	84191
Cytogenetics	15q22.31
Summary	Component of the cytosolic iron-sulfur protein assembly (CIA) complex, a multiprotein complex that mediates the incorporation of iron-sulfur cluster into extramitochondrial Fe/S proteins (PubMed:23891004). As a CIA complex component and in collaboration with CIAO1 specifically matures ACO1 and stabilizes IREB2, connecting cytosolic iron-sulfur protein maturation with cellular iron regulation (PubMed:23891004). May play a role in chromosome segregation through establishment of sister chromatid cohesion. May induce apoptosis in collaboration with APAF1 (PubMed:25716227).[UniProtKB/Swiss-Prot Function]

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