HINT1 (NM_005340) Human Mass Spec Standard

Specifications

Product Data
Description	HINT1 MS Standard C13 and N15-labeled recombinant protein (NP_005331)
Species	Human
Expression Host	HEK293
Expression cDNA Clone or AA Sequence	RC203319
Predicted MW	13.8 kDa
Protein Sequence	Sequence Link (showhide) >RC203319 protein sequence Red=Cloning site Green=Tags(s) MADEIAKAQVARPGGDTIFGKIIRKEIPAKIIFEDDRCLAFHDISPQAPTHFLVIPKKHISQISVAEDDD ESLLGHLMIVGKKCAADLGLNKGYRMVVNEGSDGGQSVYHVHLHVLGGRQMHWPPG TRTRPLEQKLISEEDLAANDILDYKDDDDKV
Tag	C-Myc/DDK
Purity	> 80% as determined by SDS-PAGE and Coomassie blue staining
Concentration	>0.05 µg/µL as determined by microplate BCA method
Labeling Method	Labeled with [U- 13C6, 15N4]-L-Arginine and [U- 13C6, 15N2]-L-Lysine
Buffer	25 mM Tris-HCl, 100 mM glycine, pH 7.3
Reference Data
RefSeq	NP_005331
RefSeq Size	689
RefSeq ORF	378
Synonyms	HINT; NMAN; PKCI-1; PRKCNH1
Locus ID	3094
Cytogenetics	5q23.3
Summary	This gene encodes a protein that hydrolyzes purine nucleotide phosphoramidates substrates, including AMP-morpholidate, AMP-N-alanine methyl ester, AMP-alpha-acetyl lysine methyl ester, and AMP-NH2. The encoded protein interacts with these substrates via a histidine triad motif. This gene is considered a tumor suppressor gene. In addition, mutations in this gene can cause autosomal recessive neuromyotonia and axonal neuropathy. There are several related pseudogenes on chromosome 7. Several transcript variants have been observed. [provided by RefSeq, Dec 2015]

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