PI3 (NM_002638) Human Mass Spec Standard

Specifications

Product Data
Description	PI3 MS Standard C13 and N15-labeled recombinant protein (NP_002629)
Species	Human
Expression Host	HEK293
Expression cDNA Clone or AA Sequence	RC203136
Predicted MW	12.3 kDa
Protein Sequence	Sequence Link (showhide) >RC203136 protein sequence Red=Cloning site Green=Tags(s) MRASSFLIVVVFLIAGTLVLEAAVTGVPVKGQDTVKGRVPFNGQDPVKGQVSVKGQDKVKAQEPVKGPVS TKPGSCPIILIRCAMLNPPNRCLKDTDCPGIKKCCEGSCGMACFVPQ TRTRPLEQKLISEEDLAANDILDYKDDDDKV
Tag	C-Myc/DDK
Purity	> 80% as determined by SDS-PAGE and Coomassie blue staining
Concentration	>0.05 µg/µL as determined by microplate BCA method
Labeling Method	Labeled with [U- 13C6, 15N4]-L-Arginine and [U- 13C6, 15N2]-L-Lysine
Buffer	25 mM Tris-HCl, 100 mM glycine, pH 7.3
Reference Data
RefSeq	NP_002629
RefSeq Size	579
RefSeq ORF	351
Synonyms	cementoin; ESI; SKALP; WAP3; WFDC14
Locus ID	5266
Cytogenetics	20q13.12
Summary	This gene encodes an elastase-specific inhibitor that functions as an antimicrobial peptide against Gram-positive and Gram-negative bacteria, and fungal pathogens. The protein contains a WAP-type four-disulfide core (WFDC) domain, and is thus a member of the WFDC domain family. Most WFDC gene members are localized to chromosome 20q12-q13 in two clusters: centromeric and telomeric. This gene belongs to the centromeric cluster. Expression of this gene is upgulated by bacterial lipopolysaccharides and cytokines. [provided by RefSeq, Oct 2014]
Protein Families	Secreted Protein, Transmembrane

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