THG1L (NM_017872) Human Mass Spec Standard

Specifications

Product Data
Description	THG1L MS Standard C13 and N15-labeled recombinant protein (NP_060342)
Species	Human
Expression Host	HEK293
Expression cDNA Clone or AA Sequence	RC202845
Predicted MW	34.8 kDa
Protein Sequence	Sequence Link (showhide) >RC202845 protein sequence Red=Cloning site Green=Tags(s) MWGACKVKVHDSLATISITLRRYLRLGATMAKSKFEYVRDFEADDTCLAHCWVVVRLDGRNFHRFAEKHN FAKPNDSRALQLMTKCAQTVMEELEDIVIAYGQSDEYSFVFKRKTNWFKRRASKFMTHVASQFASSYVFY WRDYFEDQPLLYPPGFDGRVVVYPSNQTLKDYLSWRQADCHINNLYNTVFWALIQQSGLTPVQAQGRLQG TLAADKNEILFSEFNINYNNEPPMYRKGTVLIWQKVDEVMTKEIKLPTEMEGKKMAVTRTRTKPVPLHCD IIGDAFWKEHPEILDEDS TRTRPLEQKLISEEDLAANDILDYKDDDDKV
Tag	C-Myc/DDK
Purity	> 80% as determined by SDS-PAGE and Coomassie blue staining
Concentration	>0.05 µg/µL as determined by microplate BCA method
Labeling Method	Labeled with [U- 13C6, 15N4]-L-Arginine and [U- 13C6, 15N2]-L-Lysine
Buffer	25 mM Tris-HCl, 100 mM glycine, pH 7.3
Reference Data
RefSeq	NP_060342
RefSeq Size	1320
RefSeq ORF	894
Synonyms	hTHG1; ICF45; IHG-1; IHG1; SCAR28; THG1
Locus ID	54974
Cytogenetics	5q33.3
Summary	The protein encoded by this gene is a mitochondrial protein that is induced by high levels of glucose and is associated with diabetic nephropathy. The encoded protein appears to increase mitochondrial biogenesis, which could lead to renal fibrosis. Another function of this protein is that of a guanyltransferase, adding GMP to the 5' end of tRNA(His). Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2015]

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