TBCA (NM_004607) Human Mass Spec Standard

Specifications

Product Data
Description	TBCA MS Standard C13 and N15-labeled recombinant protein (NP_004598)
Species	Human
Expression Host	HEK293
Expression cDNA Clone or AA Sequence	RC202032
Predicted MW	12.9 kDa
Protein Sequence	Sequence Link (showhide) >RC202032 protein sequence Red=Cloning site Green=Tags(s) MADPRVRQIKIKTGVVKRLVKEKVMYEKEAKQQEEKIEKMRAEDGENYDIKKQAEILQESRMMIPDCQRR LEAAYLDLQRILENEKDLEEAEEYKEARLVLDSVKLEA TRTRPLEQKLISEEDLAANDILDYKDDDDKV
Tag	C-Myc/DDK
Purity	> 80% as determined by SDS-PAGE and Coomassie blue staining
Concentration	>0.05 µg/µL as determined by microplate BCA method
Labeling Method	Labeled with [U- 13C6, 15N4]-L-Arginine and [U- 13C6, 15N2]-L-Lysine
Buffer	25 mM Tris-HCl, 100 mM glycine, pH 7.3
Reference Data
RefSeq	NP_004598
RefSeq Size	679
RefSeq ORF	324
Locus ID	6902
Cytogenetics	5q14.1
Summary	The product of this gene is one of four proteins (cofactors A, D, E, and C) involved in the pathway leading to correctly folded beta-tubulin from folding intermediates. Cofactors A and D are believed to play a role in capturing and stabilizing beta-tubulin intermediates in a quasi-native confirmation. Cofactor E binds to the cofactor D/beta-tubulin complex; interaction with cofactor C then causes the release of beta-tubulin polypeptides that are committed to the native state. This gene encodes chaperonin cofactor A. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2014]

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