RTF2 (NM_016407) Human Mass Spec Standard

Specifications

Product Data
Description	C20orf43 MS Standard C13 and N15-labeled recombinant protein (NP_057491)
Species	Human
Expression Host	HEK293
Expression cDNA Clone or AA Sequence	RC201652
Predicted MW	33.9 kDa
Protein Sequence	Sequence Link (showhide) >RC201652 protein sequence Red=Cloning site Green=Tags(s) MGCDGGTIPKRHELVKGPKKVEKVDKDAELVAQWNYCTLSQEILRRPIVACELGRLYNKDAVIEFLLDKS AEKALGKAASHIKSIKNVTELKLSDNPAWEGDKGNTKGDKHDDLQRARFICPVVGLEMNGRHRFCFLRCC GCVFSERALKEIKAEVCHTCGAAFQEDDVIVLNGTKEDVDVLKTRMEERRLRAKLEKKTKKPKAAESVSK PDVSEEAPGPSKVKTGKPEEASLDSREKKTNLAPKSTAMNESSSGKAGKPPCGATKRSIADSEESEAYKS LFTTHSSAKRSKEESAHWVTHTSYCF TRTRPLEQKLISEEDLAANDILDYKDDDDKV
Tag	C-Myc/DDK
Purity	> 80% as determined by SDS-PAGE and Coomassie blue staining
Concentration	>0.05 µg/µL as determined by microplate BCA method
Labeling Method	Labeled with [U- 13C6, 15N4]-L-Arginine and [U- 13C6, 15N2]-L-Lysine
Buffer	25 mM Tris-HCl, 100 mM glycine, pH 7.3
Reference Data
RefSeq	NP_057491
RefSeq Size	1672
RefSeq ORF	918
Synonyms	C20orf43; CDAO5; HSPC164; RTFDC1; SHUJUN-3
Locus ID	51507
Cytogenetics	20q13.31
Summary	Replication termination factor which is a component of the elongating replisome (Probable). Required for ATR pathway signaling upon DNA damage and has a positive activity during DNA replication. Might function to facilitate fork pausing at replication fork barriers like the rDNA. May be globally required to stimulate ATR signaling after the fork stalls or encounters a lesion (Probable). Interacts with nascent DNA (PubMed:29290612).[UniProtKB/Swiss-Prot Function]

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