FBXL12 (NM_017703) Human Mass Spec Standard

Specifications

Product Data
Description	FBXL12 MS Standard C13 and N15-labeled recombinant protein (NP_060173)
Species	Human
Expression Host	HEK293
Expression cDNA Clone or AA Sequence	RC200178
Predicted MW	37 kDa
Protein Sequence	Sequence Link (showhide) >RC200178 protein sequence Red=Cloning site Green=Tags(s) MATLVELPDSVLLEIFSYLPVRDRIRISRVCHRWKRLVDDRWLWRHVDLTLYTMRPKVMWHLLRRYMASR LHSLRMGGYLFSGSQAPQLSPALLRALGQKCPNLKRLCLHVADLSMVPITSLPSTLRTLELHSCEISMAW LHKQQDPTVLPLLECIVLDRVPAFRDEHLQGLTRFRALRSLVLGGTYRVTETGLDAGLQELSYLQRLEVL GCTLSADSTLLAISRHLRDVRKIRLTVRGLSAPGLAVLEGMPALESLCLQGPLVTPEMPSPTEILSSCLT MPKLRVLELQGLGWEGQEAEKILCKGLPHCMVIVRACPKESMDWWM TRTRPLEQKLISEEDLAANDILDYKDDDDKV
Tag	C-Myc/DDK
Purity	> 80% as determined by SDS-PAGE and Coomassie blue staining
Concentration	>0.05 µg/µL as determined by microplate BCA method
Labeling Method	Labeled with [U- 13C6, 15N4]-L-Arginine and [U- 13C6, 15N2]-L-Lysine
Buffer	25 mM Tris-HCl, 100 mM glycine, pH 7.3
Reference Data
RefSeq	NP_060173
RefSeq Size	1876
RefSeq ORF	978
Synonyms	Fbl12
Locus ID	54850
Cytogenetics	19p13.2
Summary	Members of the F-box protein family, such as FBXL12, are characterized by an approximately 40-amino acid F-box motif. SCF complexes, formed by SKP1 (MIM 601434), cullin (see CUL1; MIM 603134), and F-box proteins, act as protein-ubiquitin ligases. F-box proteins interact with SKP1 through the F box, and they interact with ubiquitination targets through other protein interaction domains (Jin et al., 2004 [PubMed 15520277]).[supplied by OMIM, Mar 2008]
Protein Families	Druggable Genome

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