14 3 3 eta (YWHAH) (NM_003405) Human Mass Spec Standard

Specifications

Product Data
Description	YWHAH MS Standard C13 and N15-labeled recombinant protein (NP_003396)
Species	Human
Expression Host	HEK293
Expression cDNA Clone or AA Sequence	RC200013
Predicted MW	28.2 kDa
Protein Sequence	Sequence Link (showhide) >RC200013 protein sequence Red=Cloning site Green=Tags(s) MGDREQLLQRARLAEQAERYDDMASAMKAVTELNEPLSNEDRNLLSVAYKNVVGARRSSWRVISSIEQKT MADGNEKKLEKVKAYREKIEKELETVCNDVLSLLDKFLIKNCNDFQYESKVFYLKMKGDYYRYLAEVASG EKKNSVVEASEAAYKEAFEISKEQMQPTHPIRLGLALNFSVFYYEIQNAPEQACLLAKQAFDDAIAELDT LNEDSYKDSTLIMQLLRDNLTLWTSDQQDEEAGEGN TRTRPLEQKLISEEDLAANDILDYKDDDDKV
Tag	C-Myc/DDK
Purity	> 80% as determined by SDS-PAGE and Coomassie blue staining
Concentration	>0.05 µg/µL as determined by microplate BCA method
Labeling Method	Labeled with [U- 13C6, 15N4]-L-Arginine and [U- 13C6, 15N2]-L-Lysine
Buffer	25 mM Tris-HCl, 100 mM glycine, pH 7.3
Reference Data
RefSeq	NP_003396
RefSeq Size	1807
RefSeq ORF	738
Synonyms	YWHA1
Locus ID	7533
Cytogenetics	22q12.3
Summary	This gene product belongs to the 14-3-3 family of proteins which mediate signal transduction by binding to phosphoserine-containing proteins. This highly conserved protein family is found in both plants and mammals, and this protein is 99% identical to the mouse, rat and bovine orthologs. This gene contains a 7 bp repeat sequence in its 5' UTR, and changes in the number of this repeat have been associated with early-onset schizophrenia and psychotic bipolar disorder. [provided by RefSeq, Jun 2009]
Protein Families	Druggable Genome, Transcription Factors
Protein Pathways	Cell cycle, Neurotrophin signaling pathway, Oocyte meiosis

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