Myd88 Mouse Gene Knockout Kit (CRISPR)
CAT#: KN310583RB
Myd88 - mouse gene knockout kit via CRISPR, HDR mediated
HDR-mediated knockout kit validation
CNY 12,260.00
Specifications
Product Data | |
Format | 2 gRNA vectors, 1 RFP-BSD donor, 1 scramble control |
Donor DNA | RFP-BSD |
Symbol | Myd88 |
Locus ID | 17874 |
Kit Components |
KN310583G1, Myd88 gRNA vector 1 in pCas-Guide CRISPR vector KN310583G2, Myd88 gRNA vector 2 in pCas-Guide CRISPR vector KN310583RB-D, donor DNA containing left and right homologous arms and RFP-BSD functional cassette. GE100003, scramble sequence in pCas-Guide vector |
Disclaimer | These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPR technology. The system has been functionally validated for knocking-in the cassette downstream the native promoter. The efficiency of the knock-out varies due to the nature of the biology and the complexity of the experimental process. |
Reference Data | |
RefSeq | NM_010851 |
Summary | Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response (PubMed:9697844). Acts via IRAK1, IRAK2, IRF7 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response (PubMed:9575168, PubMed:9697844). Increases IL-8 transcription. Involved in IL-18-mediated signaling pathway (PubMed:9697844). Isoform 2 is defective in its ability to induce IRAK phosphorylation and NF-kappa-B activation and can function as a negative regulator of activation by IL-1 or lipopolysaccharide (LPS) (PubMed:11909531). Activates IRF1 resulting in its rapid migration into the nucleus to mediate an efficient induction of IFN-beta, NOS2/INOS, and IL12A genes (PubMed:17018642). MyD88-mediated signaling in intestinal epithelial cells is crucial for maintenance of gut homeostasis and controls the expression of the antimicrobial lectin REG3G in the small intestine (PubMed:17635956, PubMed:21998396). Mediates leukocyte recruitment at the inflammatory site (PubMed:18941239).[UniProtKB/Swiss-Prot Function] |
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基因表达相关资源 |
Other Versions
SKU | Description | Size | Price |
---|---|---|---|
KN310583 | Myd88 - mouse gene knockout kit via CRISPR, HDR mediated |
CNY 12,260.00 |
|
KN310583BN | Myd88 - mouse gene knockout kit via CRISPR, HDR mediated |
CNY 12,260.00 |
|
KN310583LP | Myd88 - mouse gene knockout kit via CRISPR, HDR mediated |
CNY 12,260.00 |
|
KN510583 | Myd88 - KN2.0, Mouse gene knockout kit via CRISPR, non-homology mediated. |
CNY 8,680.00 |
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GA202782 | Myd88 CRISPRa kit - CRISPR gene activation of mouse myeloid differentiation primary response gene 88 |
CNY 12,255.00 |