XIAP Human Gene Knockout Kit (CRISPR)
CAT#: KN207627BN
XIAP - human gene knockout kit via CRISPR, HDR mediated
HDR-mediated knockout kit validation
CNY 12,260.00
Specifications
Product Data | |
Format | 2 gRNA vectors, 1 mBFP-Neo donor, 1 scramble control |
Donor DNA | mBFP-Neo |
Symbol | XIAP |
Locus ID | 331 |
Kit Components |
KN207627G1, XIAP gRNA vector 1 in pCas-Guide CRISPR vector KN207627G2, XIAP gRNA vector 2 in pCas-Guide CRISPR vector KN207627BN-D, donor DNA containing left and right homologous arms and mBFP-Neo functional cassette. GE100003, scramble sequence in pCas-Guide vector |
Disclaimer | These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPR technology. The system has been functionally validated for knocking-in the cassette downstream the native promoter. The efficiency of the knock-out varies due to the nature of the biology and the complexity of the experimental process. |
Reference Data | |
RefSeq | NM_001167, NM_001204401, NR_037916 |
Synonyms | API3; BIRC4; hIAP-3; hIAP3; IAP-3; ILP1; MIHA; XLP2 |
Summary | This gene encodes a protein that belongs to a family of apoptotic suppressor proteins. Members of this family share a conserved motif termed, baculovirus IAP repeat, which is necessary for their anti-apoptotic function. This protein functions through binding to tumor necrosis factor receptor-associated factors TRAF1 and TRAF2 and inhibits apoptosis induced by menadione, a potent inducer of free radicals, and interleukin 1-beta converting enzyme. This protein also inhibits at least two members of the caspase family of cell-death proteases, caspase-3 and caspase-7. Mutations in this gene are the cause of X-linked lymphoproliferative syndrome. Alternate splicing results in multiple transcript variants. Pseudogenes of this gene are found on chromosomes 2 and 11.[provided by RefSeq, Feb 2011] |
Documents
Product Manuals |
FAQs |
Resources
基因表达相关资源 |
Other Versions
SKU | Description | Size | Price |
---|---|---|---|
KN207627 | XIAP - human gene knockout kit via CRISPR, HDR mediated |
CNY 12,260.00 |
|
KN207627LP | XIAP - human gene knockout kit via CRISPR, HDR mediated |
CNY 12,260.00 |
|
KN207627RB | XIAP - human gene knockout kit via CRISPR, HDR mediated |
CNY 12,260.00 |
|
KN407627 | XIAP - KN2.0, Human gene knockout kit via CRISPR, non-homology mediated. |
CNY 8,680.00 |
|
GA100232 | XIAP CRISPRa kit - CRISPR gene activation of human X-linked inhibitor of apoptosis |
CNY 12,255.00 |