Apolipoprotein E (APOE) Human Gene Knockout Kit (CRISPR)

Specifications

Product Data
Format	2 gRNA vectors, 1 Luciferase-Puro donor, 1 scramble control
Donor DNA	Luciferase-Puro
Symbol	Apolipoprotein E
Locus ID	348
Kit Components	KN200395G1, Apolipoprotein E gRNA vector 1 in pCas-Guide CRISPR vector KN200395G2, Apolipoprotein E gRNA vector 2 in pCas-Guide CRISPR vector KN200395LP-D, donor DNA containing left and right homologous arms and Luciferase-Puro functional cassette. GE100003, scramble sequence in pCas-Guide vector
Reference Data
RefSeq	NM_000041, NM_001302688, NM_001302689, NM_001302690, NM_001302691
Synonyms	AD2; APO-E; LDLCQ5; LPG
Summary	The protein encoded by this gene is a major apoprotein of the chylomicron. It binds to a specific liver and peripheral cell receptor, and is essential for the normal catabolism of triglyceride-rich lipoprotein constituents. This gene maps to chromosome 19 in a cluster with the related apolipoprotein C1 and C2 genes. Mutations in this gene result in familial dysbetalipoproteinemia, or type III hyperlipoproteinemia (HLP III), in which increased plasma cholesterol and triglycerides are the consequence of impaired clearance of chylomicron and VLDL remnants. [provided by RefSeq, Jun 2016]

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