Mouse Btbd18 activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	Btbd18
Locus ID	100270744
Kit Components	GA219337G1, Btbd18 gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA219337G2, Btbd18 gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA219337G3, Btbd18 gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Reference Data
RefSeq	NM_001145100
Synonyms	Btbd18-ps; Gm13718; OTTMUSG00000013494
Summary	Specifically required during spermatogenesis to promote expression of piRNA precursors. The piRNA metabolic process mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and governs the methylation and subsequent repression of transposons, which is essential for the germline integrity. Acts by facilitating transcription elongation at piRNA loci during pachytene.[UniProtKB/Swiss-Prot Function]

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