Mouse Parp10 activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	Parp10
Locus ID	671535
Kit Components	GA218526G1, Parp10 gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA218526G2, Parp10 gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA218526G3, Parp10 gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Reference Data
RefSeq	NM_001163575, NM_001163576
Summary	ADP-ribosyltransferase that mediates mono-ADP-ribosylation of glutamate and aspartate residues on target proteins. In contrast to PARP1 and PARP2, it is not able to mediate poly-ADP-ribosylation. Catalyzes mono-ADP-ribosylation of GSK3B, leading to negatively regulate GSK3B kinase activity. Involved in translesion DNA synthesis in response to DNA damage via its interaction with PCNA.[UniProtKB/Swiss-Prot Function]

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