Mouse Mn1 activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	Mn1
Locus ID	433938
Kit Components	GA217595G1, Mn1 gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA217595G2, Mn1 gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA217595G3, Mn1 gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Reference Data
RefSeq	NM_001081235
Synonyms	AA003644; AA009236
Summary	Transcriptional activator which specifically regulates expression of TBX22 in the posterior region of the developing palate (PubMed:18948418). Required during later stages of palate development for normal growth and medial fusion of the palatal shelves (PubMed:18948418). Promotes maturation and normal function of calvarial osteoblasts, including expression of the osteoclastogenic cytokine TNFSF11/RANKL (PubMed:19386590). Necessary for normal development of the membranous bones of the skull (PubMed:15870292). May play a role in tumor suppression (By similarity).[UniProtKB/Swiss-Prot Function]

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