Mouse Aim2 activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	Aim2
Locus ID	383619
Kit Components	GA217273G1, Aim2 gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA217273G2, Aim2 gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA217273G3, Aim2 gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Reference Data
RefSeq	NM_001013779
Synonyms	Gm1313; Ifi210
Summary	Involved in innate immune response by recognizing cytosolic double-stranded DNA and inducing caspase-1-activating inflammasome formation in macrophages. Upon binding to DNA is thought to undergo oligomerization and to associate with PYCARD initiating the recruitment of caspase-1 precusrsor and processing of interleukin-1 beta and interleukin-18. Detects cytosolic dsDNA of viral and bacterial origin in a non-sequence-specific manner. Can also trigger PYCARD-dependent, caspase-1-independent cell death that involves caspase-8.[UniProtKB/Swiss-Prot Function]

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