Mouse Atxn7l3b activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	Atxn7l3b
Locus ID	382423
Kit Components	GA217249G1, Atxn7l3b gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA217249G2, Atxn7l3b gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA217249G3, Atxn7l3b gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Reference Data
RefSeq	NM_001033474
Synonyms	4921506J03Rik; 6230409E21Rik; AI315132; ENSMUSG00000074747
Summary	By binding to ENY2, interferes with the nuclear functions of the deubiquitinase (DUB) module of the SAGA complex which consists of ENY2, ATXN7, ATXN7L3 and the histone deubiquitinating component USP22. Affects USP22 DUB activity toward histones indirectly by changing the subcellular distribution of ENY2 and altering ENY2 availability for ATXN7L3 interaction. Regulates H2B monoubiquitination (H2Bub1) levels through cytoplasmic sequestration of ENY2 resulting in loss of nuclear ENY2-ATXN7L3 association which destabilizes ATXN7L3. Affects protein expression levels of ENY2 and ATXN7L3.[UniProtKB/Swiss-Prot Function]

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