Mouse Ccdc84 activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	Ccdc84
Locus ID	382073
Kit Components	GA217215G1, Ccdc84 gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA217215G2, Ccdc84 gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA217215G3, Ccdc84 gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Reference Data
RefSeq	NM_201372, NR_151775, NR_151776
Synonyms	D630044F24Rik; Gm1114
Summary	Negative regulator of centrosome duplication. Constrains centriole number by modulating the degradation of the centrosome-duplication-associated protein SASS6 in an acetylation-dependent manner. SIRT1 deacetylates CENATAC in G1 phase, allowing for SASS6 accumulation on the centrosome and subsequent procentriole assembly. The CENATAC acetylation level is restored in mitosis by NAT10, promoting SASS6 proteasome degradation by facilitating SASS6 binding to APC/C E3 ubiquitin-protein ligase complex/FZR1.[UniProtKB/Swiss-Prot Function]

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