Mouse Shisa6 activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	Shisa6
Locus ID	380702
Kit Components	GA217017G1, Shisa6 gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA217017G2, Shisa6 gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA217017G3, Shisa6 gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Reference Data
RefSeq	NM_001034874
Synonyms	ckamp52; Gm879
Summary	Involved in maintenance of high-frequency synaptic transmission at hippocampal CA3-CA1 synapses. Regulates AMPA-type glutamate receptor (AMPAR) immobilization at postsynaptic density keeping the channels in an activated state in the presence of glutamate and preventing synaptic depression (PubMed:26931375). May play a role in self-renewal and differentiation of spermatogonial stem cells by inhibiting canonical Wnt signaling pathway (PubMed:28196692).[UniProtKB/Swiss-Prot Function]

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