Mouse Bend3 activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	Bend3
Locus ID	331623
Kit Components	GA216892G1, Bend3 gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA216892G2, Bend3 gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA216892G3, Bend3 gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Reference Data
RefSeq	NM_199028, NM_001359600, NM_001359601
Synonyms	mKIAA1553
Summary	Transcriptional repressor which associates with the NoRC (nucleolar remodeling complex) complex and plays a key role in repressing rDNA transcription. The sumoylated form modulates the stability of the NoRC complex component BAZ2A/TIP5 by controlling its USP21-mediated deubiquitination (By similarity). Binds to unmethylated major satellite DNA and is involved in the recruitment of the Polycomb repressive complex 2 (PRC2) to major satellites (PubMed:25457167). Stimulates the ERCC6L translocase and ATPase activities (By similarity).[UniProtKB/Swiss-Prot Function]

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