Mouse Dock1 activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	Dock1
Locus ID	330662
Kit Components	GA216839G1, Dock1 gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA216839G2, Dock1 gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA216839G3, Dock1 gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Reference Data
RefSeq	NM_001033420
Synonyms	9130006G06Rik; AI854900; D630004B07Rik
Summary	Involved in cytoskeletal rearrangements required for phagocytosis of apoptotic cells and cell motility. Along with DOCK1, mediates CRK/CRKL regulation of epithelial and endothelial cell spreading and migration on type IV collagen. Functions as a guanine nucleotide exchange factor (GEF), which activates Rac Rho small GTPases by exchanging bound GDP for free GTP. Its GEF activity may be enhanced by ELMO1.[UniProtKB/Swiss-Prot Function]

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