Mouse Ubash3a activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	Ubash3a
Locus ID	328795
Kit Components	GA216694G1, Ubash3a gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA216694G2, Ubash3a gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA216694G3, Ubash3a gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Reference Data
RefSeq	NM_177823
Synonyms	5830413C03Rik; C330001M22; Sts-2; TULA; TULA-1
Summary	Interferes with CBL-mediated down-regulation and degradation of receptor-type tyrosine kinases. Promotes accumulation of activated target receptors, such as T-cell receptors, EGFR and PDGFRB, on the cell surface. May inhibit dynamin-dependent endocytic pathways by functionally sequestering dynamin via its SH3 domain (By similarity). Exhibits negligigle protein tyrosine phosphatase activity at neutral pH. May act as a dominant-negative regulator of UBASH3B-dependent dephosphorylation.[UniProtKB/Swiss-Prot Function]

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