Mouse Zmiz1 activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	Zmiz1
Locus ID	328365
Kit Components	GA216661G1, Zmiz1 gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA216661G2, Zmiz1 gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA216661G3, Zmiz1 gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Reference Data
RefSeq	NM_001310666, NM_183208
Synonyms	BC065120; E330020C23; ENSMUSG00000072684; Gm10397; I920194n01; Rai17; Zimp10
Summary	Acts as transcriptional coactivator. Increases ligand-dependent transcriptional activity of AR and promotes AR sumoylation. The stimulation of AR activity is dependent upon sumoylation (By similarity). Involved in transcriptional activation of a subset of NOTCH1 target genes including MYC. Involved in thymocyte and T cell development (PubMed:26522984).[UniProtKB/Swiss-Prot Function]

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