Mouse Iffo1 activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	Iffo1
Locus ID	320678
Kit Components	GA216542G1, Iffo1 gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA216542G2, Iffo1 gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA216542G3, Iffo1 gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Reference Data
RefSeq	NM_001039669, NM_001302778, NM_001302779, NM_178787, NR_126495
Synonyms	4733401N06Rik; A930037G23Rik; HOM-TES-103; Iffo
Summary	Nuclear matrix protein involved in the immobilization of broken DNA ends and the suppression of chromosome translocation during DNA double-strand breaks (DSBs) (PubMed:31548606). Interacts with the nuclear lamina component LMNA, resulting in the formation of a nucleoskeleton that will relocalize to the DSB sites in a XRCC4-dependent manner and promote the immobilization of the broken ends, thereby preventing chromosome translocation (PubMed:31548606). Acts as a scaffold that allows the DNA repair protein XRCC4 and LMNA to assemble into a complex at the DSB sites (PubMed:31548606).[UniProtKB/Swiss-Prot Function]

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